Tefluthrin

Tefluthrin

SCHEMBL4622567

Cc1c(F)c(F)c(COC(=O)[C@H]2[C@@H](C=C(Cl)C(F)(F)F)C2(C)C)c(F)c1F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 1.00
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
LMNA P02545 3/20 0.42
ATM Q13315 2/20 0.42
ADRA2A P08913 1/20 0.42
CNR1 P21554 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TSHR P16473 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tefluthrin SCHEMBL20823 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL16536934 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL2740810 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL14427331 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL4622566 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL1920781 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL8769136 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL1898396 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL21112033 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM
Tefluthrin SCHEMBL1963314 1.00 TDP1 (1.00) TDP1MEN1KMT2ALMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0538246-B1 PYRETHROID FORMULATIONS OF REDUCED PARESTHESIA ZENECA INC (US) 1995-02-22 EP claimed
EP-0538246-A1 PYRETHROID FORMULATIONS OF REDUCED PARESTHESIA. ICI AMERICA INC (US) 1993-04-28 EP claimed
WO-1990008467-A1 PYRETHROID FORMULATIONS OF REDUCED PARESTHESIA ICI AMERICAS INC. (US) 1990-08-09 WO claimed
EP-1339666-B1 PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL SYNGENTA LTD (GB) 2008-04-02 EP disclosed
US-6894195-B2 Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol SYNGENTA LIMITED (GB) 2005-05-17 US disclosed
US-20050054886-A1 Preparation of 4-methyl-2, 3, 5, 6-tetrafluorobenzyl alcohol SYNGENTA LIMITED (GB) 2005-03-10 US disclosed
EP-1332125-B1 PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL SYNGENTA LTD (GB) 2004-09-29 EP disclosed
US-20040063993-A1 Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol SYNGENTA LIMITED (GB) 2004-04-01 US disclosed
EP-1339666-A1 PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL Syngenta Limited (GB) 2003-09-03 EP disclosed
EP-1332125-A1 PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL Syngenta Limited (GB) 2003-08-06 EP disclosed
WO-2002034706-A1 PREPARATION OF 4-METHYL-2, 3, 5, 6-TETRAFLUOROBENZYL ALCOHOL SYNGENTA LIMITED (GB) 2002-05-02 WO disclosed
WO-2002034707-A1 PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL SYNGENTA LIMITED (GB) 2002-05-02 WO disclosed
EP-0538246-A1 PYRETHROID FORMULATIONS OF REDUCED PARESTHESIA. ICI AMERICA INC (US) 1993-04-28 EP disclosed
WO-1990008467-A1 PYRETHROID FORMULATIONS OF REDUCED PARESTHESIA ICI AMERICAS INC. (US) 1990-08-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040063993-A1 Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol METTL14, CYP4F2, METTL3 TDP1 4018/4885MEN1 1618/4885KMT2A 80/4885
US-20050054886-A1 Preparation of 4-methyl-2, 3, 5, 6-tetrafluorobenzyl alcohol ADH1C, ADH1A, TET3 TDP1 2022/4885MEN1 694/4885KMT2A 201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.