Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.69 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.69 |
| ▸ | GABRP | O00591 | 2/20 | 0.55 |
| ▸ | GABRD | O14764 | 2/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.55 |
| ▸ | GABRE | P78334 | 2/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL21145282 | 0.86 | GABRP (0.65) | TSHRTP53EGLN1EGLN3GABRP | |
| Maleic Acid SCHEMBL8957408 | 0.86 | GABRP (0.65) | TSHRTP53EGLN1EGLN3GABRP | |
| Fumaric Acid SCHEMBL21145284 | 0.86 | GABRP (0.65) | TSHRTP53EGLN1EGLN3GABRP | |
| Fumaric Acid SCHEMBL27654460 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3GABRP | |
| Maleic Acid SCHEMBL1924596 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3GABRP | |
| Fumaric Acid SCHEMBL27634187 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3GABRP | |
| Fumaric Acid SCHEMBL1924598 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3GABRP | |
| Maleic Acid SCHEMBL15660586 | 0.84 | TSHR (0.82) | TSHRTP53EGLN1EGLN3GABRP | |
| Fumaric Acid SCHEMBL3998225 | 0.83 | — | — | |
| Maleic Acid SCHEMBL20487516 | 0.83 | TSHR (1.00) | TSHRTP53EGLN1EGLN3GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575133-B2 | Novel phospholipase A1, process for its preparation and the use thereof | SANKYO LIFETECH COMPANY LTD (JP) | 2008-06-18 | — | — | EP | disclosed |
| EP-0575133-B1 | Novel phospholipase A1, process for its preparation and the use thereof | SANKYO CO (JP) | 2002-08-21 | — | — | EP | disclosed |
| US-5538874-A | PREPARATION OF LYSOPHOSPHOLIPIDS, ASPERGILLUS | SANKYO COMPANY, LIMITED (JP) | 1996-07-23 | — | — | US | disclosed |
| US-5521080-A | FROM ASPERGILLUS | SANKYO COMPANY, LIMITED (JP) | 1996-05-28 | — | — | US | disclosed |
| US-5378623-A | Aspergillus culture product | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |