Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 4/20 | 0.65 |
| ▸ | GABRD | O14764 | 4/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.65 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.65 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.65 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.65 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.65 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.65 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.65 |
| ▸ | GABRE | P78334 | 4/20 | 0.65 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.65 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.65 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.65 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL21145282 | 1.00 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Maleic Acid SCHEMBL8957408 | 1.00 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fumaric Acid SCHEMBL1835366 | 0.90 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Maleic Acid SCHEMBL3118041 | 0.90 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fumaric Acid SCHEMBL1835364 | 0.90 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fumaric Acid SCHEMBL28768987 | 0.88 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fumaric Acid SCHEMBL28068205 | 0.88 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fumaric Acid SCHEMBL31016717 | 0.88 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Maleic Acid SCHEMBL4623286 | 0.86 | TSHR (0.69) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Fumaric Acid SCHEMBL10400867 | 0.83 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2020-06-11 | — | — | US | disclosed |
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-08-08 | — | — | US | disclosed |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-07-18 | — | — | US | disclosed |
| CN-1325399-A | Pyrroloindoles, pyridoindoles and azaindoles as 5-HT 2C agonists | CEREBRUS RES LTD (GB) | 2001-12-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, S100A10 | MEN1 3369/4885KMT2A 242/4885GABRP 3714/4885 |
| US-20190216703-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, SRRM2, IK | MEN1 4505/4885KMT2A 912/4885GABRP 2481/4885 |
| US-20190216714-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CD44, PCNA | MEN1 2001/4885KMT2A 97/4885GABRP 3593/4885 |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, DSG1 | MEN1 3038/4885KMT2A 59/4885GABRP 2157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.