Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12049795 | 0.87 | TRPV1 (0.66) | EPHX2NR1H4TRPV1 | |
| SCHEMBL4624020 | 0.80 | EPHX2 (0.59) | EPHX2NR1H4TRPV1 | |
| SCHEMBL6561391 | 0.80 | EPHX2 (0.59) | EPHX2NR1H4TRPV1CA1CA2 | |
| SCHEMBL4891719 | 0.79 | EPHX2 (0.72) | EPHX2NR1H4TRPV1 | |
| SCHEMBL12060854 | 0.77 | NR1H4 (0.44) | EPHX2NR1H4CA1CA2 | |
| SCHEMBL22059471 | 0.73 | EPHX2 (1.00) | EPHX2NR1H4CA1CA2 | |
| SCHEMBL6563007 | 0.73 | EPHX2 (0.63) | EPHX2NR1H4TRPV1 | |
| SCHEMBL4891046 | 0.68 | CA1 (0.73) | EPHX2NR1H4TRPV1CA1CA2 | |
| SCHEMBL4622076 | 0.67 | TRPV1 (0.76) | TRPV1 | |
| SCHEMBL1107981 | 0.67 | ALDH1A1 (0.64) | EPHX2NR1H4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071650-B2 | Vanilloid receptor modulators; analgesic, antiinflammatory and antiulcer effects; such as 1-(1H-indol-5-ylmethyl)-3-phenethylthiourea | PACIFIC CORPORATION (KR) | 2011-12-06 | — | — | US | disclosed |
| CN-100439332-C | Novel thiourea derivatives and the pharmaceutical compositions containing thd same | PACFIC CORP (KR) | 2008-12-03 | — | — | CN | disclosed |
| EP-1303483-B1 | NOVEL THIOUREA DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORP (KR) | 2008-04-23 | — | — | EP | disclosed |
| US-20080064687-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | SUH YOUNG G | 2008-03-13 | — | — | US | disclosed |
| US-20030153596-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | PACIFIC CORPORATION (KR) | 2003-08-14 | — | — | US | disclosed |
| CN-1418191-A | Novel thiourea derivatives and pharmaceutical compositions containing the same | PACFIC CORP (KR) | 2003-05-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153596-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | TAS2R40, TAS1R2, TAS2R45 | EPHX2 3810/4885NR1H4 690/4885TRPV1 18/4885 |
| US-20080064687-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | TRPV1, TRPA1, TAS2R5 | EPHX2 3840/4885NR1H4 640/4885TRPV1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.