Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SELL | P14151 | 1/20 | 0.52 |
| ▸ | SELP | P16109 | 1/20 | 0.52 |
| ▸ | SELE | P16581 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629164 | 0.77 | ALDH1A1 (0.75) | ALDH1A1HPGDLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL12998051 | 0.77 | ALDH1A1 (0.55) | ALDH1A1HPGDLMNASMN1; SMN2KMT2A | |
| SCHEMBL4803124 | 0.77 | LMNA (0.58) | ALDH1A1HPGDLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL3393320 | 0.76 | RAB9A (0.58) | ALDH1A1HPGDLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL11900441 | 0.76 | ALDH1A1 (0.70) | ALDH1A1HPGDLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL4040223 | 0.74 | ALDH1A1 (0.82) | ALDH1A1HPGDLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL4802411 | 0.73 | LMNA (0.54) | ALDH1A1HPGDLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8437112 | 0.73 | ALDH1A1 (0.79) | ALDH1A1HPGDLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6164465 | 0.73 | LMNA (0.64) | ALDH1A1HPGDLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL593127 | 0.73 | FOLH1 (0.61) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633716-A4 | BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-03-26 | — | — | EP | claimed |
| EP-1633716-A2 | BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004094372-A2 | COMPOUNDS USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-04 | — | — | WO | claimed |