Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.40 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.39 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629910 | 0.89 | SLC6A1 (0.55) | TSHRSLC6A1SLC6A11SLC6A13LMNA | |
| SCHEMBL3224577 | 0.88 | POLB (0.50) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL4125597 | 0.79 | — | — | |
| SCHEMBL2916439 | 0.79 | — | — | |
| SCHEMBL15082262 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL23779176 | 0.78 | CHRNB2 (0.52) | TSHRGABRA5GABRB2GABRPGABRD | |
| Hydrochloric Acid SCHEMBL30751515 | 0.78 | CHRNB2 (0.52) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL16671005 | 0.77 | GABRA5 (0.38) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL4630365 | 0.77 | GNAI3 (0.42) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL19454411 | 0.77 | BRPF1 (0.39) | TSHRGABRA5GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |