Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630173 | 0.88 | HRH4 (0.45) | HTR6HRH4HRH3VCPHTR1A | |
| SCHEMBL4629545 | 0.88 | VCP (0.47) | HTR6HRH4VCPHTR2A | |
| SCHEMBL4630016 | 0.87 | CA2 (0.46) | HTR6HRH4HRH3CNR1BCAT1 | |
| Hydrochloric Acid SCHEMBL4628914 | 0.87 | VCP (0.46) | HTR6HRH4VCPHTR1AHTR2A | |
| SCHEMBL4630008 | 0.85 | HTR6 (0.42) | HTR6HRH4HRH3CYP3A4ITK | |
| SCHEMBL4628912 | 0.83 | CYP3A4 (0.41) | HRH4HRH3CNR1CYP3A4CYP2D6 | |
| SCHEMBL4629550 | 0.82 | POLB (0.44) | HTR6HRH4HRH3CNR1ITK | |
| SCHEMBL4630007 | 0.81 | CYP3A4 (0.49) | HTR6HRH4HRH3CYP3A4CYP2D6 | |
| SCHEMBL4629706 | 0.79 | HTR6 (0.45) | HTR6HRH4CNR1AXLPDE5A | |
| SCHEMBL2273734 | 0.75 | HTR6 (0.54) | HTR6CYP3A4HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919896-A1 | AMINOARYL SULPHONAMIDE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS. | Suven Life Sciences Limited (IN) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007020652-A1 | AMINOARYL SULPHONAMIDE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS. | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-02-22 | — | — | WO | disclosed |