Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3448897 | 0.87 | CHRNB2 (0.33) | — | |
| SCHEMBL3449345 | 0.78 | CHRNB2 (0.32) | — | |
| SCHEMBL4629956 | 0.77 | MAPT (0.36) | — | |
| SCHEMBL8718223 | 0.77 | MAPT (0.36) | — | |
| SCHEMBL3450210 | 0.76 | NPC1 (0.40) | SIGMAR1 | |
| SCHEMBL5875452 | 0.76 | LMNA (0.35) | GNAI3GNAO1GNAI1SIGMAR1 | |
| SCHEMBL8370619 | 0.74 | F2 (0.30) | — | |
| SCHEMBL3449600 | 0.73 | ALDH1A1 (0.40) | — | |
| SCHEMBL8710374 | 0.72 | CHRNB2 (0.47) | SIGMAR1 | |
| SCHEMBL4073459 | 0.71 | CA2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |