Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229101 | 0.75 | ALDH1A1 (0.33) | ALDH1A1NPC1 | |
| SCHEMBL8308888 | 0.72 | ALOX15 (0.43) | HTTALDH1A1ALOX15NPC1KDM4E | |
| SCHEMBL6040793 | 0.71 | ALDH1A1 (0.51) | LMNATDP1THRBALDH1A1TSHR | |
| SCHEMBL7172154 | 0.70 | THRB (0.45) | LMNAHTTALPGTDP1THRB | |
| SCHEMBL11495165 | 0.69 | ALOX15 (0.41) | LMNAHTTALDH1A1ALOX15NPC1 | |
| SCHEMBL11009587 | 0.69 | ALOX5 (0.38) | LMNAHTTALDH1A1TSHRALOX15 | |
| SCHEMBL11814891 | 0.69 | CYP3A4 (0.47) | LMNAHTTTDP1ALDH1A1TSHR | |
| SCHEMBL11815114 | 0.68 | KDM4E (0.38) | LMNAHTTALPGTDP1ALDH1A1 | |
| SCHEMBL11809284 | 0.68 | LMNA (0.41) | LMNAHTTALPGTDP1ALDH1A1 | |
| SCHEMBL9346852 | 0.68 | THRB (0.38) | LMNAHTTALPGTDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004103057-A2 | COMPOSITIONS AND METHODS FOR INDUCING ADIPOSE TISSUE CELL DEATH | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2004-12-02 | — | — | WO | claimed |
| US-20040235922-A1 | Compositions and methods for inducing adipose tissue cell death | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2004-11-25 | — | — | US | claimed |
| EP-0608568-B1 | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents | AMERICAN CYANAMID CO (US) | 1998-03-11 | — | — | EP | claimed |
| EP-0608568-A1 | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents | AMERICAN CYANAMID COMPANY (US) | 1994-08-03 | — | — | EP | claimed |
| US-5106867-A | Administering substituted 1,3-benzodioxole antilipogenic agent | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | claimed |
| CN-101007804-B | 1,3-benzodioxole-2,2-dicarboxylic acid derivatives and their preparation method and medicinal uses | INST PHARM & TOXICOLOGY AMMS | 2011-05-11 | — | — | CN | disclosed |
| CN-101007804-B | 1,3-benzodioxole-2,2-dicarboxylic acid derivatives and their preparation method and medicinal uses | INST PHARM & TOXICOLOGY AMMS | 2011-05-11 | — | — | CN | disclosed |
| EP-1650186-B1 | Novel dicarboxylic acid derivatives | BIOPROJET SOC CIV (FR) | 2008-06-04 | — | — | EP | disclosed |
| CN-101007804-A | 1,3-benzodioxole-2,2-dicarboxylic acid derivatives and their preparation method and medicinal uses | POISON MED INST PLA MED ACAD (CN) | 2007-08-01 | — | — | CN | disclosed |
| CN-101007804-A | 1,3-benzodioxole-2,2-dicarboxylic acid derivatives and their preparation method and medicinal uses | POISON MED INST PLA MED ACAD (CN) | 2007-08-01 | — | — | CN | disclosed |
| CN-1874791-A | Pharmaceutical composition containing beta-3-adrenoceptor agonists and alpha antagonists and/or 5-alpha reductase inhibitors | BOEHRINGER INGELHEIM INT (DE) | 2006-12-06 | — | — | CN | disclosed |
| US-6890955-B2 | Aryloxypropanolamine derivatives, method of preparation and applications thereof | VIRBAC SA (FR) | 2005-05-10 | — | — | US | disclosed |
| WO-1995029903-A1 | STEREOPREFERENTIAL SYNTHESIS OF 3-(1-PHENYLPROP-2-YL)-5-PHENYLOXAZOLIDINONES | CELGENE CORPORATION (US) | 1995-11-09 | — | — | WO | disclosed |
| US-5373020-A | Antidiabetic, antiobesity, hyperglycemic agents | AMERICAN CYANAMID COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| EP-0608568-A1 | Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents | AMERICAN CYANAMID COMPANY (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5245053-A | Resolution of diastereoisomers, reaction with Mosher's acid hypoglycemic agent, diabetes | AMERICAN CYANAMID COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| US-5151439-A | Antidiabetic agents or antihyperglycemic agents | AMERICAN CYANAMID COMPANY (US) | 1992-09-29 | — | — | US | disclosed |
| US-5106867-A | Administering substituted 1,3-benzodioxole antilipogenic agent | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0455006-A2 | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles | AMERICAN CYANAMID COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| US-5061727-A | ANTIOBESITY, ANTIDIABETIC, HYPOGLYCEMIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1991-10-29 | — | — | US | disclosed |