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SCHEMBL46352

SCHEMBL46352

COC(=O)C1(N(CC2CCCO2)C(=O)Cc2c(C)cc(C)cc2C)CCN(OC)CC1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.41
▸ MAPT P10636 4/20 0.40
▸ TP53 P04637 2/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ ALDH1A1 P00352 4/20 0.37
▸ KMT2A Q03164 3/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ GAA P10253 1/20 0.37
▸ OPRM1 P35372 1/20 0.37
▸ OPRD1 P41143 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ HPGD P15428 3/20 0.37
▸ RAB9A P51151 1/20 0.35
▸ OXTR P30559 1/20 0.35
▸ AVPR1A P37288 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL46380 0.87 POLB (0.40) POLBMAPTTP53SMN1; SMN2ALDH1A1
SCHEMBL15032125 0.84 ALDH1A1 (0.39) POLBMAPTTP53SMN1; SMN2ALDH1A1
SCHEMBL36994 0.83 ALDH1A1 (0.37) POLBMAPTALDH1A1KMT2AMEN1
SCHEMBL46115 0.80 ALDH1A1 (0.40) POLBMAPTALDH1A1KMT2AMEN1
SCHEMBL46049 0.79 MEN1 (0.38) SMN1; SMN2ALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL37508 0.79 OPRM1 (0.37) MAPTTP53KMT2AMEN1OPRM1
SCHEMBL37359 0.79 OPRM1 (0.35) KMT2AMEN1OPRM1OPRD1
SCHEMBL46187 0.79 OPRM1 (0.32) POLBMAPTALDH1A1KMT2AMEN1
SCHEMBL46061 0.78 MEN1 (0.34) KMT2AMEN1GAAOPRM1OPRD1
SCHEMBL15216820 0.78 OPRM1 (0.33) OPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2575469-B1 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2018-03-14 — — EP disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 — — US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 — — US disclosed
EP-2575472-B1 METHOD OF CONTROLLING NEONICOTINOID RESISTANT HEMIPTERA USING SPIROHETEROCYCLIC PYRROLIDINE DIONE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-07-19 — — EP disclosed
US-9485989-B2 Method of controlling neonicotinoid resistant hemiptera SYNGENTA PARTICIPATIONS AG (CH) 2016-11-08 — — US disclosed
US-9485989-B2 Method of controlling neonicotinoid resistant hemiptera SYNGENTA PARTICIPATIONS AG (CH) 2016-11-08 — — US disclosed
US-9462808-B2 Pesticidal compositions SYNGENTA PARTICIPANTS AG (CH) 2016-10-11 — — US disclosed
US-9462808-B2 Pesticidal compositions SYNGENTA PARTICIPANTS AG (CH) 2016-10-11 — — US disclosed
EP-2575449-B1 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2016-04-27 — — EP disclosed
US-20150259345-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA LIMITED (GB) 2015-09-17 — — US disclosed
US-20130225411-A1 PESTICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION LLC (US) 2013-08-29 — — US disclosed
US-20130225411-A1 PESTICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION LLC (US) 2013-08-29 — — US disclosed
US-20130150394-A1 PESTICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION LLC (US) 2013-06-13 — — US disclosed
WO-2011151249-A2 METHOD OF CONTROLLING NEONICOTINOID RESISTANT HEMIPTERA SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 — — WO disclosed
US-20110301031-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA CROP PROTECTION LLC (US) 2011-12-08 — — US disclosed
US-20110301031-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA CROP PROTECTION LLC (US) 2011-12-08 — — US disclosed
WO-2011151248-A1 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 — — WO disclosed
WO-2011151247-A2 PESTICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 — — WO disclosed
WO-2011151194-A1 1, 8 -DIAZASPIRO [4.5] DECANE- 2, 4 -DIONE DERIVATIVES USEFUL AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2011-12-08 — — WO disclosed
WO-2010066780-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110301031-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES DDT, THOP1, KCNH1 POLB 4584/4885MAPT 4606/4885TP53 4311/4885
US-20130150394-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, GAP43 POLB 4095/4885MAPT 4154/4885TP53 4554/4885
US-20130225411-A1 PESTICIDAL COMPOSITIONS DDT, CIP2A, CYP51A1 POLB 2598/4885MAPT 4492/4885TP53 4428/4885
US-20150259345-A1 SPIROHETEROCYCLIC N-OXYPIPERIDINES AS PESTICIDES DDT, THOP1, KCNH1 POLB 4609/4885MAPT 4728/4885TP53 4091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.