Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | ACP3 | P15309 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60955 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL28033934 | 0.79 | DPP4 (0.45) | ALDH1A1CYP3A4TAAR1TDP1 | |
| Hydrogen Sulfide SCHEMBL27610802 | 0.79 | ALDH1A1 (0.60) | ALDH1A1CHRNB2CHRNA4ACP3PTGS2 | |
| SCHEMBL16426382 | 0.79 | PTGS2 (0.54) | ALDH1A1CHRNB2CHRNA4ACP3PTGS2 | |
| SCHEMBL662302 | 0.78 | PGK1 (0.38) | KIF11 | |
| SCHEMBL1538543 | 0.77 | RXRA (0.47) | ALDH1A1CHRNB2CHRNA4PTGS2KIF11 | |
| SCHEMBL2838545 | 0.77 | ALDH1A1 (0.56) | ALDH1A1CHRNB2CHRNA4ACP3PTGS2 | |
| SCHEMBL13092431 | 0.76 | CHRNA7 (0.42) | ALDH1A1KIF11HSD17B10TDP1 | |
| SCHEMBL1539040 | 0.76 | TSHR (0.43) | — | |
| Biphenyl SCHEMBL6252617 | 0.76 | ALDH1A1 (0.64) | ALDH1A1CHRNB2CHRNA4PTGS2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118932350-A | Method for synthesizing carboxylic acid and deuterated carboxylic acid compound through electrochemical defluorination | 江西师范大学 | 2024-11-12 | — | — | CN | disclosed |
| CN-117865773-A | Preparation method of difluoromethyl aromatic compound based on palladium-catalyzed decarbonylation coupling | 大连理工大学 | 2024-04-12 | — | — | CN | disclosed |
| EP-3053875-B1 | FLUORINATING AGENT | DAIKIN IND LTD (JP) | 2022-09-28 | — | — | EP | disclosed |
| CN-110655539-B | Method for synthesizing cis-difluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation | 四川大学 | 2021-11-12 | — | — | CN | disclosed |
| CN-111574322-A | Preparation method of difluoromethyl aromatic compound | 南京工业大学 | 2020-08-25 | — | — | CN | disclosed |
| WO-2020037109-A1 | PROCESSES FOR FLUORINATION | DOW AGROSCIENCES LLC (US) | 2020-02-20 | — | — | WO | disclosed |
| CN-110655539-A | Method for synthesizing cis-difluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation | 四川大学 | 2020-01-07 | — | — | CN | disclosed |
| US-10479681-B2 | Fluorinating agent | DAIKIN INDUSTRIES, LTD. (JP) | 2019-11-19 | — | — | US | disclosed |
| US-20190152779-A1 | FLUORINATING AGENT | DAIKIN INDUSTRIES, LTD. (JP) | 2019-05-23 | — | — | US | disclosed |
| US-10233080-B2 | Fluorinating agent | DAIKIN INDUSTRIES, LTD. (JP) | 2019-03-19 | — | — | US | disclosed |
| US-9475756-B2 | Difluoromethylation of aryl and vinyl iodides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475756-B2 | Difluoromethylation of aryl and vinyl iodides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475756-B2 | Difluoromethylation of aryl and vinyl iodides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-10-25 | — | — | US | disclosed |
| EP-3053875-A1 | FLUORINATING AGENT | Daikin Industries, Ltd. (JP) | 2016-08-10 | — | — | EP | disclosed |
| US-20150045580-A1 | DIFLUOROMETHYLATION OF ARYL AND VINYL IODIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | disclosed |
| US-20150045580-A1 | DIFLUOROMETHYLATION OF ARYL AND VINYL IODIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | disclosed |
| US-20150045580-A1 | DIFLUOROMETHYLATION OF ARYL AND VINYL IODIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | disclosed |
| WO-2013134296-A1 | DIFLUOROMETHYLATION OF ARYL AND VINYL IODIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-09-12 | — | — | WO | disclosed |
| EP-1931425-A1 | ANTITUBERCULOUS COMPOSITION COMPRISING OXAZOLE COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007043542-A1 | ANTITUBERCULOUS COMPOSITION COMPRISING OXAZOLE COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479681-B2 | Fluorinating agent | AFF2, AFF4, AFF1 | ALDH1A1 2167/4885CHRNB2 3476/4885CHRNA4 3228/4885 |
| US-10233080-B2 | Fluorinating agent | AFF2, AFF4, AFF1 | ALDH1A1 2167/4885CHRNB2 3476/4885CHRNA4 3228/4885 |
| US-20190152779-A1 | FLUORINATING AGENT | AFF2, AFF4, AFF1 | ALDH1A1 2167/4885CHRNB2 3476/4885CHRNA4 3228/4885 |
| US-20150045580-A1 | DIFLUOROMETHYLATION OF ARYL AND VINYL IODIDES | CUL2, CUL3, CYP4F2 | ALDH1A1 2999/4885CHRNB2 2523/4885CHRNA4 3536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.