Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 10/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637470 | 0.84 | SCN9A (0.39) | EPAS1VEGFASCN9AMEN1KMT2A | |
| SCHEMBL4638451 | 0.83 | SCN9A (0.38) | EPAS1SCN9AMEN1KMT2AHTR2A | |
| SCHEMBL4637612 | 0.83 | HTT (0.43) | EPAS1SCN9AMEN1KMT2AHTR2A | |
| SCHEMBL2067780 | 0.78 | PTGDR2 (0.41) | EPAS1VEGFAMEN1KMT2A | |
| SCHEMBL4637574 | 0.75 | EPAS1 (0.51) | EPAS1VEGFASCN9ASLC22A12 | |
| SCHEMBL4637490 | 0.72 | EPAS1 (0.43) | EPAS1SCN9AKMT2APGR | |
| SCHEMBL4637551 | 0.71 | CYP1A2 (0.39) | SCN9ASLC22A12MEN1KMT2AHTR2A | |
| SCHEMBL12504669 | 0.70 | ACLY (0.51) | EPAS1MEN1KMT2A | |
| SCHEMBL4638321 | 0.70 | PLA2G7 (0.40) | EPAS1VEGFASCN9A | |
| SCHEMBL4637581 | 0.69 | SCN9A (0.41) | EPAS1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |