Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637470 | 0.86 | SCN9A (0.39) | SCN9AMEN1KMT2AEPAS1HTR2A | |
| SCHEMBL4637612 | 0.85 | HTT (0.43) | SCN9AMEN1KMT2AEPAS1HTR2A | |
| SCHEMBL4638348 | 0.83 | EPAS1 (0.39) | SCN9AMEN1KMT2AEPAS1HTR2A | |
| SCHEMBL2065645 | 0.76 | NR3C1 (0.43) | MEN1KMT2AEPAS1 | |
| SCHEMBL4637490 | 0.73 | EPAS1 (0.43) | SCN9AKMT2AEPAS1HTTALDH1A1 | |
| SCHEMBL4637551 | 0.73 | CYP1A2 (0.39) | SCN9AMEN1KMT2AHTR2AHTR2C | |
| SCHEMBL4638321 | 0.71 | PLA2G7 (0.40) | SCN9AEPAS1PLA2G7PTPN1HTT | |
| SCHEMBL4637581 | 0.71 | SCN9A (0.41) | SCN9AEPAS1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4637574 | 0.70 | EPAS1 (0.51) | SCN9AEPAS1PLA2G7 | |
| SCHEMBL4637444 | 0.69 | EPAS1 (0.53) | EPAS1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |