Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.47 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.47 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | S100B | P04271 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22604978 | 0.94 | SKP2 (0.89) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL11869178 | 0.92 | SKP2 (0.86) | SKP2CYP3A4HPGDRAB9AALDH1A1 | |
| SCHEMBL3514830 | 0.90 | SKP2 (0.81) | SKP2CYP3A4CYP1A2MAPK1ALDH1A1 | |
| SCHEMBL28125839 | 0.88 | SKP2 (0.78) | SKP2CYP3A4MAPK1ALDH1A1TSHR | |
| SCHEMBL7747145 | 0.88 | SKP2 (0.78) | SKP2CYP3A4NPC1RAB9AALDH1A1 | |
| SCHEMBL841783 | 0.85 | SKP2 (0.73) | SKP2CYP3A4CYP1A2MAPK1ALDH1A1 | |
| SCHEMBL31634603 | 0.85 | SKP2 (0.73) | SKP2CYP3A4CYP1A2MAPK1ALDH1A1 | |
| SCHEMBL23093003 | 0.84 | SKP2 (0.72) | SKP2CYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL3238669 | 0.84 | SKP2 (0.72) | SKP2CYP3A4CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL7204931 | 0.83 | SKP2 (0.71) | SKP2CYP3A4HPGDNPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050547-A1 | MITOCHONDRIAL COMPLEX I INHIBITORS AND METHODS OF USE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-03-18 | — | — | WO | claimed |
| EP-1773768-B1 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2018-08-22 | — | — | EP | claimed |
| EP-2954896-A1 | Small molecule inhibitors of the E3 Ligase Skp2 in depression and other diseases | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2015-12-16 | — | — | EP | claimed |
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | claimed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | claimed |
| EP-3377473-B1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2024-06-19 | — | — | EP | disclosed |
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| CN-108884058-B | Macrocyclic broad spectrum antibiotics | 阿奇克斯制药公司 | 2022-04-29 | — | — | CN | disclosed |
| EP-3307733-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2021-10-20 | — | — | EP | disclosed |
| EP-3307733-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2021-10-20 | — | — | EP | disclosed |
| US-7078400-B2 | 20-HETE synthase inhibitor | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-18 | — | — | US | disclosed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | disclosed |
| EP-1226819-B1 | INHIBITOR FOR 20-HETE-YIELDING ENZYME | TAISHO PHARMACEUTICAL CO LTD (JP) | 2006-01-18 | — | — | EP | disclosed |
| US-6864254-B1 | Inhibitor for 20-hete-yielding enzyme | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2005-03-08 | — | — | US | disclosed |
| US-20040110830-A1 | 20-HETE synthase inhibitor | TAISHO PHARMACEUTICAL CO., LTD. | 2004-06-10 | — | — | US | disclosed |
| EP-1226819-A1 | INHIBITOR FOR 20-HETE-YIELDING ENZYME | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-4173645-A | INSECTICIDES, MITICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1979-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133817-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | SKP2 1002/4885CYP3A4 3437/4885CYP2D6 3451/4885 |
| US-20040110830-A1 | 20-HETE synthase inhibitor | ALOX5, ALOX15, ALOX15B | SKP2 2790/4885CYP3A4 347/4885CYP2D6 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.