Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL28890119 | 0.81 | PKM (0.40) | RIPK1CASP1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL16291997 | 0.81 | NPEPPS (0.38) | RIPK1CASP1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2998444 | 0.72 | GPR119 (0.54) | GPR119RIPK1GRM5USP30POLB | |
| SCHEMBL31228209 | 0.72 | GPR119 (0.54) | GPR119RIPK1GRM5USP30POLB | |
| SCHEMBL23053142 | 0.71 | ALDH1A1 (0.40) | RIPK1CASP1ALDH1A1POLBKDM4E | |
| SCHEMBL29785757 | 0.70 | GPR119 (0.52) | GPR119RIPK1GRM5USP30ALDH1A1 | |
| SCHEMBL30469398 | 0.70 | GPR119 (0.65) | GPR119USP30POLBKDM4EMMP13 | |
| SCHEMBL4080053 | 0.70 | GPR119 (0.65) | GPR119USP30POLBKDM4EMMP13 | |
| SCHEMBL29549924 | 0.70 | GPR119 (0.52) | GPR119RIPK1GRM5USP30ALDH1A1 | |
| SCHEMBL22039535 | 0.69 | HSD11B1 (0.54) | GPR119RIPK1ALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107567450-B | Heterocyclic compounds useful as TNF inhibitors | 百时美施贵宝公司 | 2020-03-13 | — | — | CN | disclosed |
| EP-1951234-A2 | METHOD OF INHIBITING FLT3 KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007048088-A2 | METHOD OF INHIBITING FLT3 KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-26 | — | — | WO | disclosed |
| EP-1747222-A1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | Proskelia SAS (FR) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005123734-A1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | PROSKELIA SAS (FR) | 2005-12-29 | — | — | WO | disclosed |