Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.44 |
| ▸ | CETP | P11597 | 14/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202789 | 0.86 | CETP (0.47) | CETPKCNH2 | |
| SCHEMBL4639184 | 0.83 | CETP (0.52) | CETPKCNH2 | |
| SCHEMBL4639272 | 0.81 | CETP (0.43) | CETPKCNH2 | |
| SCHEMBL1182545 | 0.79 | CETP (0.48) | CETP | |
| SCHEMBL4639707 | 0.79 | GPBAR1 (0.36) | KIF11CETP | |
| SCHEMBL4640356 | 0.76 | NOS3 (0.39) | KIF11CETP | |
| SCHEMBL4640202 | 0.75 | CETP (0.43) | CETP | |
| SCHEMBL4639357 | 0.70 | ALOX5 (0.37) | KIF11CETP | |
| SCHEMBL14534605 | 0.69 | CETP (0.56) | CETPKCNH2 | |
| SCHEMBL1184057 | 0.69 | CETP (0.64) | CETPKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951673-A2 | HETEROCYCLIC CETP INHIBITORS | Bristol-Myers Squibb Company (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062314-A2 | HETEROCYCLIC CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-31 | — | — | WO | disclosed |