Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204446 | 0.83 | HCRTR1 (0.37) | KDM4EGCKMEN1KMT2A | |
| SCHEMBL3556069 | 0.81 | AADAT (0.51) | AADATTMEM97SIGMAR1GFERNPSR1 | |
| SCHEMBL13374857 | 0.78 | TMEM97 (0.49) | AADATTMEM97SIGMAR1TSHRL3MBTL1 | |
| SCHEMBL3556108 | 0.77 | NOS1 (0.55) | AADATTMEM97SIGMAR1TSHRKDM4E | |
| SCHEMBL7576252 | 0.76 | SIGMAR1 (0.53) | AADATTMEM97SIGMAR1PREPCTSK | |
| SCHEMBL29174258 | 0.75 | HSD11B1 (0.54) | AADATTMEM97SIGMAR1TSHRL3MBTL1 | |
| SCHEMBL955550 | 0.75 | AADAT (0.50) | AADATTMEM97SIGMAR1TSHRL3MBTL1 | |
| SCHEMBL955548 | 0.75 | AADAT (0.50) | AADATTMEM97SIGMAR1TSHRL3MBTL1 | |
| SCHEMBL29277932 | 0.73 | PREP (0.52) | AADATTMEM97SIGMAR1TSHRL3MBTL1 | |
| SCHEMBL28716810 | 0.72 | TMEM97 (0.50) | AADATTMEM97SIGMAR1GFERNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954694-A1 | IMIDAZOLE DERIVATIVES AS NITRIC OXIDE SYNTHASE DIMERISATION INHIBITOR | Kalypsys, Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007062410-A1 | IMIDAZOLE DERIVATIVES AS NITRIC OXIDE SYNTHASE DIMERISATION INHIBITOR | KALYPSYS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |