Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.35 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GCK | P35557 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640604 | 0.83 | AADAT (0.45) | KDM4EGCKMEN1KMT2A | |
| SCHEMBL5200371 | 0.77 | NOS1 (0.36) | HCRTR1NOS1NOS2 | |
| SCHEMBL2637675 | 0.74 | SMN1; SMN2 (0.39) | HCRTR1UCHL1USP30HCRTR2KDM4E | |
| SCHEMBL5199947 | 0.72 | HRH3 (0.35) | HCRTR1HCRTR2KDM4EALDH1A1MEN1 | |
| SCHEMBL934063 | 0.72 | HTR2B (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL1293292 | 0.72 | HTR2B (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL5203615 | 0.71 | UCHL1 (0.38) | HCRTR1UCHL1USP30HCRTR2GRM5 | |
| SCHEMBL4641452 | 0.71 | SCN10A (0.35) | HCRTR1HCRTR2 | |
| SCHEMBL3566595 | 0.70 | NOS2 (0.59) | NOS1NOS2KDM4EALDH1A1MEN1 | |
| SCHEMBL5202000 | 0.70 | MEN1 (0.33) | HCRTR1HCRTR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007062417-A1 | METHODS OF PREPARING 2-IMIDAZOL-1-YL-4-METHYL-6-PYRROLIDIN-2-YL-PYRIMIDINE AND 4-(1-ALKYLPYRROLIDIN-2-YL)-2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDINE DERIVATIVES | KALYPSYS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |