SCHEMBL4642449

SCHEMBL4642449

FC(F)[Si](Cl)(c1ccccc1)C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 2/20 0.32
NR1H3 Q13133 2/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32
ESR1 P03372 1/20 0.30
ESR2 Q92731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21438997 0.72 TSHR (0.38) NR1H2NR1H3ALDH1A1TSHRESR1
SCHEMBL23701150 0.72 TSHR (0.38) NR1H2NR1H3ALDH1A1TSHRESR1
SCHEMBL3160992 0.71 NR1H2 (0.33) NR1H2NR1H3ALDH1A1TSHRESR1
SCHEMBL5569284 0.70 NR1H2 (0.40) NR1H2NR1H3ALDH1A1TSHRESR1
SCHEMBL1049841 0.66 ALDH1A1 (0.41) NR1H2NR1H3ALDH1A1TSHRESR1
SCHEMBL1053231 0.66 ALDH1A1 (0.41) NR1H2NR1H3ALDH1A1TSHRESR1
SCHEMBL14777395 0.66 ESR1 (0.32) NR1H2NR1H3ALDH1A1ESR1ESR2
SCHEMBL1051334 0.66 ALDH1A1 (0.41) NR1H2NR1H3ALDH1A1TSHRESR1
SCHEMBL9745209 0.65 RIPK1 (0.31) ESR1ESR2
SCHEMBL705847 0.65 ESR1 (0.40) NR1H2NR1H3ALDH1A1TSHRESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190225629-A1 METHOD FOR PREPARING SILAHYDROCARBONS UNIVERSITY OF DELAWARE (US) 2019-07-25 US disclosed
WO-2018064163-A1 METHOD FOR PREPARING SILAHYDROCARBONS UNIVERSITY OF DELAWARE (US) 2018-04-05 WO disclosed
CN-106589508-A Environment-friendly reclaimed rubber shoe sole 福建省惠安县万事达鞋塑有限公司 2017-04-26 CN disclosed
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed
EP-1487928-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT Jotun AS (NO) 2004-12-22 EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 WO disclosed
EP-0355497-A2 Polyorganosiloxane compounds Chisso Corporation (JP) 1990-02-28 EP disclosed
EP-0353709-A2 Polyorganosiloxane compounds with amino group Chisso Corporation (JP) 1990-02-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225629-A1 METHOD FOR PREPARING SILAHYDROCARBONS MCM6, CCNY, RIOX2 NR1H2 3284/4885NR1H3 3018/4885ALDH1A1 2045/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.