SCHEMBL4642545

SCHEMBL4642545

Cc1ccc([SiH2]OC(=O)C(C)(C(=O)O[SiH2]c2ccc(C)cc2)C(=O)O[SiH2]c2ccc(C)cc2Cl)cc1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.36
NPC1 O15118 3/20 0.36
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PKM P14618 1/20 0.32
ALOX15 P16050 1/20 0.32
PDK1 Q15118 1/20 0.32
PDK2 Q15119 1/20 0.32
PDK3 Q15120 1/20 0.32
PDK4 Q16654 1/20 0.32
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MEN1 O00255 1/20 0.30
LMNA P02545 1/20 0.30
MAPK1 P28482 1/20 0.30
GFER P55789 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4644556 0.85 TRPA1 (0.33) RAB9ANPC1KDM4EALDH1A1LMNA
SCHEMBL4647341 0.73 ALDH1A1 (0.34) RAB9AHPGDSMN1; SMN2PKMALDH1A1
SCHEMBL4643854 0.72 ALDH1A1 (0.37) RAB9AHPGDSMN1; SMN2PKMALDH1A1
SCHEMBL4643587 0.70 ALDH1A1 (0.34) RAB9AHPGDSMN1; SMN2PKMALDH1A1
SCHEMBL4644321 0.68 ALDH1A1 (0.38) RAB9ANPC1HPGDSMN1; SMN2KDM4E
SCHEMBL4645470 0.66 LMNA (0.32) RAB9ANPC1SMN1; SMN2ALDH1A1LMNA
SCHEMBL4645863 0.64 LMNA (0.30) LMNA
SCHEMBL4643335 0.64 ALDH1A1 (0.38) HPGDSMN1; SMN2PKMKDM4EALDH1A1
SCHEMBL6555621 0.63 LMNA (0.36) NPC1SMN1; SMN2ALDH1A1LMNAKMT2A
SCHEMBL4642079 0.61 ALDH1A1 (0.33) NPC1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed
EP-1487928-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT Jotun AS (NO) 2004-12-22 EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 WO disclosed