SCHEMBL4643335

SCHEMBL4643335

Cc1ccc([SiH2]OC(=O)[C](C(=O)O[SiH2]c2ccc(C)cc2)C(=O)O[SiH2]c2ccc(C)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.38
LMNA P02545 3/20 0.38
CES2 O00748 3/20 0.38
CES1 P23141 3/20 0.38
TDP1 Q9NUW8 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
HTT P42858 3/20 0.34
PKM P14618 2/20 0.34
ATM Q13315 2/20 0.34
NPSR1 Q6W5P4 2/20 0.34
GAA P10253 2/20 0.34
HPGD P15428 1/20 0.34
NLRP1 Q9C000 1/20 0.34
MEN1 O00255 1/20 0.34
NTSR1 P30989 1/20 0.34
KMT2A Q03164 1/20 0.34
SRD5A2 P31213 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
HDAC1 Q13547 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4643854 0.78 ALDH1A1 (0.37) ALDH1A1LMNACES2CES1TDP1
SCHEMBL4647341 0.75 ALDH1A1 (0.34) ALDH1A1LMNACES2CES1TDP1
SCHEMBL4643587 0.75 ALDH1A1 (0.34) ALDH1A1LMNACES2CES1TDP1
SCHEMBL6555621 0.75 LMNA (0.36) ALDH1A1LMNACES2CES1TDP1
SCHEMBL4858072 0.69 ACHE (0.47) ALDH1A1LMNATDP1GAAMEN1
SCHEMBL2873305 0.67 ACHE (0.44) ALDH1A1LMNATDP1MEN1KMT2A
P-Xylene SCHEMBL4557367 0.66 ALDH1A1 (0.63) ALDH1A1LMNACES2CES1TDP1
SCHEMBL3481787 0.62 ACHE (0.38) ALDH1A1TDP1SMN1; SMN2HTTGAA
SCHEMBL17835350 0.62 ACHE (0.38) ALDH1A1TDP1SMN1; SMN2MEN1KMT2A
SCHEMBL16301269 0.62 ACHE (0.61) ALDH1A1LMNACES2CES1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed