SCHEMBL4642667

SCHEMBL4642667

N=C(N)NCCC[C@H](NS(=O)(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 4/20 0.52
KCNA5 P22460 1/20 0.51
MMP1 P03956 1/20 0.47
MMP2 P08253 1/20 0.47
MMP9 P14780 1/20 0.47
MMP8 P22894 1/20 0.47
NPY4R P50391 7/20 0.47
NPY1R P25929 4/20 0.47
NPY2R P49146 3/20 0.47
F10 P00742 3/20 0.47
F2 P00734 2/20 0.45
PLAU P00749 1/20 0.44
PLG P00747 1/20 0.44
KISS1R Q969F8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7117030 0.91 KCNA5 (0.49) NPY5RKCNA5NPY4RNPY1RNPY2R
SCHEMBL2922269 0.89 NPY4R (0.47) NPY5RNPY4RNPY1RNPY2RKISS1R
SCHEMBL2926943 0.88 ITGB3 (0.51) NPY5RNPY4RNPY1RNPY2RKISS1R
SCHEMBL3298844 0.87 F2 (0.52) NPY5RF10F2
SCHEMBL2927716 0.87 KCNA5 (0.49) NPY5RKCNA5MMP1MMP2MMP9
SCHEMBL2924336 0.87 KCNA5 (0.55) NPY5RKCNA5MMP1MMP2MMP9
SCHEMBL2924338 0.87 KCNA5 (0.55) NPY5RKCNA5MMP1MMP2MMP9
SCHEMBL7534730 0.87 BMP1 (0.51) NPY5RMMP2MMP9NPY4RNPY1R
SCHEMBL6551505 0.86 MMP1 (0.44) NPY5RKCNA5MMP1MMP2MMP9
SCHEMBL2928771 0.85 F2 (0.53) NPY5RNPY4RNPY1RNPY2RF10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1678196-B1 SULFONYLAMINO-PEPTIDOMIMETICS ACTIVE ON THE SOMATOSTATIN RECEPTOR SUBTYPES 4 (SSTR4) AND 1 (SSTR1) WURSTER SIEGFRIED (FI) 2008-08-13 EP disclosed
US-20070129313-A1 Sulfonylamino-peptidomimetics active on the somatostatin receptor subtypes 4 (sstr4) and 1 (sstr1) SIEGFRIED WURSTER (FI) 2007-06-07 US disclosed
EP-1678196-A1 SULFONYLAMINO-PEPTIDOMIMETICS ACTIVE ON THE SOMATOSTATIN RECEPTOR SUBTYPES 4 (SSTR4) AND 1 (SSTR1) Oy Juvantia Pharma Ltd (FI) 2006-07-12 EP disclosed
WO-2005033124-A1 SULFONYLAMINO-PEPTIDOMIMETICS ACTIVE ON THE SOMATOSTATIN RECEPTOR SUBTYPES 4 (SSTR4) AND 1 (SSTR1) OY JUVANTIA PHARMA LTD (FI) 2005-04-14 WO disclosed
US-20030144310-A1 Molecules specific for NPFF receptors and uses thereof H. LUNDBECK A/S (DK) 2003-07-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070129313-A1 Sulfonylamino-peptidomimetics active on the somatostatin receptor subtypes 4 (sstr4) and 1 (sstr1) SSTR4, SSTR1, SSTR3 NPY5R 25/4885KCNA5 842/4885MMP1 4273/4885
US-20030144310-A1 Molecules specific for NPFF receptors and uses thereof NPFFR1, NPFFR2, NPBWR1 NPY5R 372/4885KCNA5 2605/4885MMP1 4557/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.