Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464425 | 0.70 | HPGD (0.49) | LMNAHPGDKMT2AMEN1TSHR | |
| SCHEMBL419934 | 0.70 | LMNA (0.52) | LMNAHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7102145 | 0.69 | HPGD (0.42) | LMNAHPGDKMT2AMEN1TSHR | |
| SCHEMBL421283 | 0.68 | LMNA (0.39) | LMNAHPGDKMT2AMEN1TSHR | |
| SCHEMBL277446 | 0.68 | LMNA (0.50) | LMNAHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13030806 | 0.65 | LMNA (0.39) | LMNAHPGDKMT2AMEN1TSHR | |
| SCHEMBL1607377 | 0.65 | LMNA (0.51) | LMNAHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL535804 | 0.64 | ALDH1A1 (0.49) | LMNAHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10066895 | 0.64 | LMNA (0.44) | LMNAHPGDKMT2AMEN1TSHR | |
| SCHEMBL10035712 | 0.64 | LMNA (0.44) | LMNAHPGDKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329876-B2 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith | NEKTAR THERAPEUTICS (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120065330-A1 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith | NEKTAR THERAPEUTICS (US) | 2012-03-15 | — | — | US | disclosed |
| US-8071678-B2 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith | NEKTAR THERAPEUTICS (US) | 2011-12-06 | — | — | US | disclosed |
| US-20110065862-A1 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith | NEKTAR THERAPEUTICS (US) | 2011-03-17 | — | — | US | disclosed |
| US-7834088-B2 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith | NEKTAR THERAPEUTICS (US) | 2010-11-16 | — | — | US | disclosed |
| US-20100069571-A1 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith | NEKTAR THERAPEUTICS (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069571-A1 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith | PCTP, CETP, NGLY1 | LMNA 2605/4885HPGD 1334/4885KMT2A 2283/4885 |
| US-20120065330-A1 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith | PCTP, CETP, NGLY1 | LMNA 2605/4885HPGD 1334/4885KMT2A 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.