SCHEMBL4645814

SCHEMBL4645814

CCc1c2ccccc2c(Cl)c2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
KDM4E B2RXH2 3/20 0.39
CYP1A2 P05177 3/20 0.38
CYP2A6 P11509 2/20 0.38
HTT P42858 3/20 0.37
TP53 P04637 2/20 0.36
ALDH1A1 P00352 4/20 0.35
LMNA P02545 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
MAPT P10636 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
GMNN O75496 1/20 0.35
POLB P06746 1/20 0.35
ELANE P08246 1/20 0.35
CTSG P08311 1/20 0.35
CTSA P10619 1/20 0.35
ALOX15 P16050 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29853674 0.87 TP53 (0.45) KDM4ECYP1A2CYP2A6HTTTP53
SCHEMBL2317562 0.87 TP53 (0.45) KDM4ECYP1A2CYP2A6HTTTP53
SCHEMBL22202247 0.81 ALDH1A1 (0.55) MAOAMAOBKDM4ECYP1A2CYP2A6
SCHEMBL8821847 0.78 TP53 (0.43) KDM4ECYP1A2CYP2A6HTTTP53
SCHEMBL7918982 0.78 TP53 (0.43) KDM4ECYP1A2CYP2A6HTTTP53
SCHEMBL29440644 0.78 MAOA (0.58) MAOAMAOBCYP1A2CYP2A6HTT
SCHEMBL147819 0.78 MAOA (0.58) MAOAMAOBCYP1A2CYP2A6HTT
SCHEMBL11577554 0.77 CYP1A2 (0.47) KDM4ECYP1A2CYP2A6HTTTP53
SCHEMBL10405240 0.77 L3MBTL1 (0.56) MAOAMAOBCYP1A2CYP2A6HTT
SCHEMBL3670118 0.76 KDM4E (0.37) KDM4ECYP1A2CYP2A6HTTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4091578-B1 METHOD FOR PRODUCING PLATE DENTURE TOKUYAMA DENTAL CORP (JP) 2024-10-09 EP disclosed
US-11857385-B2 Method of producing plate denture, curable composition for stereolithography, and plate denture production kit TOKUYAMA DENTAL CORPORATION (JP) 2024-01-02 US disclosed
CN-114929158-B Method for producing denture, curable composition for photoforming, and kit for producing denture 株式会社德山齿科 2023-10-20 CN disclosed
US-20230137898-A1 METHOD OF PRODUCING PLATE DENTURE, CURABLE COMPOSITION FOR STEREOLITHOGRAPHY, AND PLATE DENTURE PRODUCTION KIT TOKUYAMA DENTAL CORPORATION (JP) 2023-05-04 US disclosed
EP-4091578-A1 METHOD FOR PRODUCING PLATE DENTURE, CURABLE STEREOLITHOGRAPHIC COMPOSITION, AND PLATE DENTURE PRODUCTION KIT Tokuyama Dental Corporation (JP) 2022-11-23 EP disclosed
CN-114929158-A Method for producing a denture, curable composition for photo-molding, and kit for producing a denture 株式会社德山齿科 2022-08-19 CN disclosed
US-11292770-B2 Pyridazinone herbicides FMC CORPORATION (US) 2022-04-05 US disclosed
EP-2934563-B1 ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND APPLICATIONS THEREOF JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENT RESEARCH (IN) 2020-07-08 EP disclosed
US-20200109123-A1 NOVEL PYRIDAZINONE HERBICIDES FMC CORPORATION 2020-04-09 US disclosed
EP-1591098-B1 Cationically curable composition for dental use TOKUYAMA CORP (JP) 2008-08-13 EP disclosed
US-7365106-B2 Cationically curable composition for dental use TOKUYAMA CORPORATION (JP) 2008-04-29 US disclosed
EP-1431315-B1 Photopolymerization initiator and photopolymerizable composition TOKUYAMA CORP (JP) 2007-10-17 EP disclosed
CN-1732883-A Cationically curable composition for dental use TOKUYAMA CORP (JP) 2006-02-15 CN disclosed
US-20050250868-A1 Cationically curable composition for dental use TOKUYAMA CORPORATION (JP) 2005-11-10 US disclosed
EP-1591098-A1 Cationically curable composition for dental use TOKUYAMA CORPORATION (JP) 2005-11-02 EP disclosed
US-20040186195-A1 Photopolymerization initiator and photopolymerizable composition TOKUYAMA CORPORATION (JP) 2004-09-23 US disclosed
CN-1513884-A Photopolymerization initiator and composition capable of photopolymerization 株式会社德山 2004-07-21 CN disclosed
EP-1431315-A2 Photopolymerization initiator and photopolymerizable composition Tokuyama Corporation (JP) 2004-06-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11292770-B2 Pyridazinone herbicides PRDX6, PRDX4, PDXK MAOA 411/4885MAOB 301/4885KDM4E 1848/4885
US-20200109123-A1 NOVEL PYRIDAZINONE HERBICIDES PRDX6, PRDX4, CHRM2 MAOA 530/4885MAOB 335/4885KDM4E 1703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.