Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.50 |
| ▸ | PAM | P19021 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.44 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30861849 | 0.92 | DGKA (0.62) | DGKAPAML3MBTL1ZDHHC20ZDHHC2 | |
| SCHEMBL16907300 | 0.87 | — | — | |
| SCHEMBL11079375 | 0.86 | DGKA (0.50) | DGKAPAML3MBTL1ZDHHC20ZDHHC2 | |
| SCHEMBL14063623 | 0.85 | DGKA (0.45) | DGKAPAML3MBTL1ZDHHC20ZDHHC2 | |
| SCHEMBL9360783 | 0.82 | ADRA2A (0.37) | DGKAZDHHC20ZDHHC2TSHRMAPT | |
| SCHEMBL5255351 | 0.81 | DGKA (0.52) | DGKAPAML3MBTL1TSHRMAPT | |
| SCHEMBL10009941 | 0.80 | DGKA (0.57) | DGKAPAMTSHRMAPTLMNA | |
| SCHEMBL5805525 | 0.79 | L3MBTL1 (0.64) | DGKAPAML3MBTL1ZDHHC20TSHR | |
| SCHEMBL6830198 | 0.79 | GSTP1 (0.38) | DGKAPAML3MBTL1ZDHHC20ZDHHC2 | |
| SCHEMBL10011617 | 0.79 | GSTP1 (0.38) | DGKAPAMTSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11814621-B2 | Expanding the chemical substrates for genetic code reprogramming | NORTHWESTERN UNIVERSITY (US) | 2023-11-14 | — | — | US | disclosed |
| US-11814621-B2 | Expanding the chemical substrates for genetic code reprogramming | NORTHWESTERN UNIVERSITY (US) | 2023-11-14 | — | — | US | disclosed |
| US-11814621-B2 | Expanding the chemical substrates for genetic code reprogramming | NORTHWESTERN UNIVERSITY (US) | 2023-11-14 | — | — | US | disclosed |
| US-20230295613-A1 | LONG CHAIN CARBON AND CYCLIC AMINO ACIDS SUBSTRATES FOR GENETIC CODE REPROGRAMMING | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2023-09-21 | — | — | US | disclosed |
| US-20230295613-A1 | LONG CHAIN CARBON AND CYCLIC AMINO ACIDS SUBSTRATES FOR GENETIC CODE REPROGRAMMING | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2023-09-21 | — | — | US | disclosed |
| CN-115867648-A | Extension of chemical substrates for genetic code reprogramming to include long chain carbons and cyclic amino acids | 西北大学 | 2023-03-28 | — | — | CN | disclosed |
| EP-4103734-A2 | LONG CHAIN CARBON AND CYCLIC AMINO ACIDS SUBSTRATES FOR GENETIC CODE REPROGRAMMING | Northwestern University (US) | 2022-12-21 | — | — | EP | disclosed |
| US-20210230586-A1 | Expanding the Chemical Substrates for Genetic Code Reprogramming | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE | 2021-07-29 | — | — | US | disclosed |
| EP-1263713-B2 | PROCESS FOR THE CARBONYLATION OF PENTENENITRILE | SHELL INT RESEARCH (NL) | 2008-08-20 | — | — | EP | disclosed |
| US-7026473-B2 | Process for the carbonylation of pentenenitrile | SHELL OIL COMPANY (US) | 2006-04-11 | — | — | US | disclosed |
| US-20040230071-A1 | Process for the carbonylation of pentenenitrile | DRENT EIT (NL) | 2004-11-18 | — | — | US | disclosed |
| US-6743911-B2 | PENTENENITRILE REACTED WITH CARBON MONOXIDE AND WATER OR ALCOHOL IN THE PRESENCE OF A SOURCE OF GROUP VIII METAL AND A BIDENTATE PHOSPHINE, ARSINE AND/OR STIBINE LIGAND TO FORM CYANOVALERIC ACID OR ESTER | SHELL OIL COMPANY | 2004-06-01 | — | — | US | disclosed |
| EP-1263713-A2 | PROCESS FOR THE CARBONYLATION OF PENTENENITRILE | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 2002-12-11 | — | — | EP | disclosed |
| US-20020045748-A1 | Process for the carbonylation of pentenenitrile | SHELL OIL COMPANY | 2002-04-18 | — | — | US | disclosed |
| WO-2001072697-A2 | PROCESS FOR THE CARBONYLATION OF PENTENENITRILE | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 2001-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040230071-A1 | Process for the carbonylation of pentenenitrile | RPS6KA1, RPS6KB1, RPS6KA6 | DGKA 2282/4885PAM 1868/4885L3MBTL1 2873/4885 |
| US-20020045748-A1 | Process for the carbonylation of pentenenitrile | PRKCE, PRKCB, PRKCH | DGKA 1006/4885PAM 937/4885L3MBTL1 4371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.