Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647478 | 0.83 | LSS (0.47) | KDM4EALDH1A1TDP1POLBMEN1 | |
| SCHEMBL3376471 | 0.82 | KDM4E (0.39) | SCN1ASCN8ANPSR1KDM4EALDH1A1 | |
| SCHEMBL3409569 | 0.75 | ADRA1A (0.37) | SCN1ASCN8AKDM4EALDH1A1POLB | |
| SCHEMBL4643540 | 0.74 | POLB (0.38) | SCN1ASCN8AKDM4EALDH1A1POLB | |
| SCHEMBL3374944 | 0.74 | PKM (0.40) | KDM4EALDH1A1POLBMEN1TP53 | |
| SCHEMBL3375942 | 0.73 | ALDH1A1 (0.37) | SCN1ASCN8AKDM4EALDH1A1POLB | |
| SCHEMBL4646472 | 0.73 | TP53 (0.36) | SCN1ASCN8AKDM4EALDH1A1POLB | |
| SCHEMBL3375273 | 0.73 | ALDH1A1 (0.41) | KDM4EALDH1A1POLBMEN1TP53 | |
| SCHEMBL3377318 | 0.73 | PKM (0.49) | POLBMEN1TP53KMT2A | |
| SCHEMBL4648354 | 0.72 | POLB (0.43) | KDM4EALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | disclosed |