Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4626033 | 0.80 | THRA (0.53) | SIGMAR1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3955227 | 0.74 | THRA (0.57) | THRATHRBGAAMAPTHPGD | |
| SCHEMBL2430208 | 0.73 | SIGMAR1 (0.53) | SIGMAR1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3954028 | 0.70 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3951997 | 0.69 | THRB (0.55) | THRATHRBGAAMAPTHPGD | |
| SCHEMBL28598401 | 0.69 | GAA (0.65) | THRATHRBGAAMAPTHPGD | |
| SCHEMBL14859644 | 0.68 | SIGMAR1 (0.70) | SIGMAR1LTA4HMAPTEGFRSMN1; SMN2 | |
| SCHEMBL1502370 | 0.66 | THRB (0.58) | THRATHRBGAAMAPTHPGD | |
| SCHEMBL8806810 | 0.66 | THRB (0.58) | THRATHRBGAAMAPTHPGD | |
| SCHEMBL8252175 | 0.66 | THRB (0.58) | THRATHRBGAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957473-A2 | PROCESS FOR PREPARING SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007067575-A2 | PROCESS FOR PREPARING SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES | WYETH (US) | 2007-06-14 | — | — | WO | disclosed |