Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28634062 | 0.83 | POLB (0.48) | POLBTDP1NPC1RAB9AMAPT | |
| SCHEMBL14642149 | 0.81 | MEN1 (0.49) | TDP1NPC1RAB9AMAPTMEN1 | |
| SCHEMBL14465838 | 0.80 | MAPT (0.50) | NPC1RAB9AMAPTMEN1CYP3A4 | |
| SCHEMBL3077318 | 0.79 | KIF11 (0.48) | POLBTDP1NPC1RAB9AMAPT | |
| SCHEMBL678436 | 0.77 | TDP1 (0.56) | POLBTDP1NPC1RAB9AMAPT | |
| SCHEMBL24879921 | 0.76 | EPHX2 (0.53) | NPC1RAB9AKIF11MEN1HTT | |
| SCHEMBL20355752 | 0.76 | HSD17B10 (0.55) | NPC1RAB9AMAPTMEN1CYP1A2 | |
| SCHEMBL28357095 | 0.75 | HTT (0.50) | POLBTDP1NPC1RAB9AMAPT | |
| SCHEMBL7940916 | 0.75 | POLB (0.44) | POLBTDP1NPC1RAB9AMAPT | |
| SCHEMBL12035256 | 0.75 | TDP1 (0.60) | POLBTDP1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1285909-B1 | PROCESS FOR THE PRODUCTION OF NITROGEN COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-08-20 | — | — | EP | disclosed |
| US-7087783-B2 | Method for preparing nitrogen-containing compounds | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-08-08 | — | — | US | disclosed |
| US-6960689-B2 | Method for preparing nitrogen-containing compounds | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6946576-B2 | Method for preparing nitrogen-containing compounds | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-09-20 | — | — | US | disclosed |
| US-20050075513-A1 | Method for preparing nitrogen-containing compounds | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-04-07 | — | — | US | disclosed |
| US-20050049421-A1 | Method for preparing nitrogen-containing compounds | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-03-03 | — | — | US | disclosed |
| US-20050043569-A1 | Method for preparing nitrogen-containing compounds | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-24 | — | — | US | disclosed |
| US-6803472-B2 | REACTING NH GROUP-CONTAINING COMPOUNDS WITH THIOCYANATES, CYANAMIDES, NITRITES OR ESTERS IN PRESENCE OF SILYLATING AGENT TO SYNTHESIZE CORRESPONDING NITROGEN-CONTAINING ADDITION OR SUBSTITUTION PRODUCTS; DIRECT, EFFICIENCY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-10-12 | — | — | US | disclosed |
| US-20030158442-A1 | Process for the production of nitrogen compounds | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-08-21 | — | — | US | disclosed |
| EP-1285909-A1 | PROCESS FOR THE PRODUCTION OF NITROGEN COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075513-A1 | Method for preparing nitrogen-containing compounds | NOS2, NOS1, NNMT | POLB 4341/4885TDP1 2035/4885NPC1 1395/4885 |
| US-20050049421-A1 | Method for preparing nitrogen-containing compounds | NOS2, NOS1, NNMT | POLB 4341/4885TDP1 2035/4885NPC1 1395/4885 |
| US-20050043569-A1 | Method for preparing nitrogen-containing compounds | NOS2, NOS1, NNMT | POLB 4341/4885TDP1 2035/4885NPC1 1395/4885 |
| US-20030158442-A1 | Process for the production of nitrogen compounds | NOS2, NOS1, NNMT | POLB 4306/4885TDP1 2651/4885NPC1 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.