SCHEMBL464909

SCHEMBL464909

C[C@H](N)C(=O)OC(=O)C[C@H](N)C(=O)OC(=O)[C@H](C)N

nearest known ligand 0.31

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.31
GRIK2 Q13002 1/20 0.31
SLC7A5 Q01650 1/20 0.31
GRIN2D O15399 1/20 0.30
GRIN3B O60391 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2A Q12879 1/20 0.30
GRIN2B Q13224 1/20 0.30
GRIN2C Q14957 1/20 0.30
GRIN3A Q8TCU5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4867035 0.86 SLC7A5 (0.48) SLC7A5
SCHEMBL17199754 0.86 GRIK1 (0.31) GRIK1GRIK2SLC7A5
SCHEMBL5707690 0.86 SLC7A5 (0.48) GRIK1GRIK2SLC7A5
SCHEMBL8679062 0.83 CHRNB2 (0.33) SLC7A5GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL6567069 0.83 BHMT (0.37) GRIK1GRIK2SLC7A5
SCHEMBL14486118 0.83 CHRNB2 (0.33) SLC7A5GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL10527497 0.82 SLC7A5 (0.45) SLC7A5
SCHEMBL7676359 0.81 SLC7A5 (0.52) SLC7A5
SCHEMBL1674752 0.81 GABRR1 (0.33) GRIK1GRIK2GRIN2DGRIN3BGRIN1
SCHEMBL867143 0.81 ALOX15 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9186394-B2 Pharmacological vitreolysis THROMBOGENICS NV (BE) 2015-11-17 US claimed
US-8834869-B2 Pharmacological vitreolysis THROMBOGENICS NV (BE) 2014-09-16 US claimed
US-20130302304-A1 PHARMACOLOGICAL VITREOLYSIS THROMBOGENICS NV (BE) 2013-11-14 US claimed
US-20130202613-A1 PHARMACOLOGICAL VITREOLYSIS THROMBOGENICS NV (BE) 2013-08-08 US claimed
US-20130195887-A1 PHARMACOLOGICAL VITREOLYSIS THROMBOGENICS NV (BE) 2013-08-01 US claimed
US-8460655-B2 Pharmacological vitreolysis THROMBOGENICS NV (BE) 2013-06-11 US claimed
US-20090081187-A1 Liquefying a vitreous and/or inducing posterior vitreous detachment of an eye via microplasmin injection; treating vision defects; preventing or reducing the risk of retinal detachment; catalytic domain of plasmin THROMB-X NV (BE) 2009-03-26 US claimed
US-20090074739-A1 non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy to the proliferative form ; treating vision defects; preventing or reducing the risk of retinal detachment; catalytic domain of plasmin THROMB-X NV (BE) 2009-03-19 US claimed
US-20080050356-A1 Liquefying a vitreous and/or inducing posterior vitreous detachment of an eye via microplasmin injection; treating vision defects; preventing or reducing the risk of retinal detachment THROMB-X NV (BE) 2008-02-28 US claimed
WO-2023063340-A1 INFORMATION ACQUISITION DEVICE, PROGRAM, RECOMBINANT VECTOR PRODUCTION METHOD, FISSION YEAST, AND GENE EXPRESSION SUPPRESSING METHOD 学校法人 久留米大学 2023-04-20 WO disclosed
US-20220162568-A1 PORE OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2022-05-26 US disclosed
EP-3953369-A1 PORE Oxford Nanopore Technologies plc (GB) 2022-02-16 EP disclosed
CN-113677693-A Hole(s) 牛津纳米孔科技公司 2021-11-19 CN disclosed
WO-2020208357-A1 PORE OXFORD NANOPORE TECHNOLOGIES LIMITED (GB) 2020-10-15 WO disclosed
EP-1581254-A4 PHARMACOLOGICAL VITREOLYSIS THROMB X NV (BE) 2007-03-28 EP disclosed
US-20060275897-A1 HIV vaccines based on Env of multiple clades of HIV DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY 2006-12-07 US disclosed
EP-1581254-A2 PHARMACOLOGICAL VITREOLYSIS Thromb-X NV (BE) 2005-10-05 EP disclosed
US-20050118158-A1 Treating or preventing an eye disorder using a composition comprising a truncated plasmin protein comprising a catalytic domain of plasmin (TPCD) THROMB-X NV (BE) 2005-06-02 US disclosed
WO-2004052228-A2 PHARMACOLOGICAL VITREOLYSIS THROMB-X NV (BE) 2004-06-24 WO disclosed
US-5006337-A For treating skin disorders MARBERT GMBH (DE) 1991-04-09 US disclosed