Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 4/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650105 | 0.91 | LTA4H (0.50) | ADORA2AADORA1LTA4H | |
| SCHEMBL4650586 | 0.91 | LTA4H (0.50) | ADORA2AADORA1LTA4H | |
| SCHEMBL4649999 | 0.85 | TLR9 (0.54) | — | |
| SCHEMBL4649197 | 0.80 | HTR2A (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3530148 | 0.77 | FGFR1 (0.52) | ADORA3ADORA2AADORA2BADORA1CA12 | |
| SCHEMBL4649413 | 0.76 | KDM4E (0.52) | ADORA2AADORA1FGFR1SRCLTA4H | |
| SCHEMBL4420934 | 0.75 | NPC1 (0.65) | NPC1RAB9ALTA4HPDGFRBPDGFRA | |
| SCHEMBL1353469 | 0.74 | HDAC1 (0.51) | NPC1PDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL4649409 | 0.74 | CHRNB2 (0.56) | — | |
| SCHEMBL3530145 | 0.74 | CA12 (0.48) | ADORA3ADORA2AADORA2BADORA1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730112-B1 | 3-((HETERO)ARYLSULFONYL)-8'[ (AMINOALKYL)OXY]QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | claimed |