Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650586 | 0.95 | LTA4H (0.50) | TLR9HRH3KCNH2 | |
| SCHEMBL4650105 | 0.95 | LTA4H (0.50) | TLR9HRH3KCNH2 | |
| SCHEMBL4649201 | 0.85 | ADORA3 (0.50) | — | |
| SCHEMBL4649193 | 0.79 | HTR2A (0.51) | HRH3HRH1 | |
| SCHEMBL4649413 | 0.78 | KDM4E (0.52) | — | |
| SCHEMBL4649409 | 0.78 | CHRNB2 (0.56) | — | |
| SCHEMBL14970452 | 0.75 | HRH3 (0.89) | HRH3HRH1KCNH2 | |
| SCHEMBL4650745 | 0.74 | HTR6 (0.47) | HRH3 | |
| SCHEMBL4650096 | 0.74 | CHRNB2 (0.47) | — | |
| SCHEMBL14058881 | 0.74 | HRH3 (0.61) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730112-B1 | 3-((HETERO)ARYLSULFONYL)-8'[ (AMINOALKYL)OXY]QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | claimed |