Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650105 | 1.00 | LTA4H (0.50) | LTA4HHRH3BACE1KCNH2ADORA2A | |
| SCHEMBL4649999 | 0.95 | TLR9 (0.54) | HRH3KCNH2TLR9 | |
| SCHEMBL4649201 | 0.91 | ADORA3 (0.50) | LTA4HADORA2AADORA1 | |
| SCHEMBL4649413 | 0.79 | KDM4E (0.52) | LTA4HADORA2AADORA1 | |
| SCHEMBL4649409 | 0.79 | CHRNB2 (0.56) | — | |
| SCHEMBL4650585 | 0.78 | HTR6 (0.52) | HRH3BACE1 | |
| SCHEMBL4649915 | 0.78 | HTR6 (0.52) | HRH3BACE1 | |
| SCHEMBL4649244 | 0.77 | HTR6 (0.53) | LTA4HHRH3 | |
| SCHEMBL3535866 | 0.77 | HRH3 (0.51) | LTA4HHRH3BACE1KCNH2ADORA2A | |
| SCHEMBL2814385 | 0.77 | LTA4H (0.55) | LTA4HHRH3TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730112-B1 | 3-((HETERO)ARYLSULFONYL)-8'[ (AMINOALKYL)OXY]QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | claimed |