Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 9/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.56 |
| ▸ | CHRNB1 | P11230 | 8/20 | 0.56 |
| ▸ | CHRNB3 | Q05901 | 8/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650018 | 0.88 | GPR119 (0.42) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL4650096 | 0.83 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL4649191 | 0.80 | CHRNB4 (0.50) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL4650586 | 0.79 | LTA4H (0.50) | — | |
| SCHEMBL4650105 | 0.79 | LTA4H (0.50) | — | |
| SCHEMBL4649412 | 0.78 | CHRM2 (0.45) | — | |
| SCHEMBL4650621 | 0.78 | LTA4H (0.48) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNA4 | |
| SCHEMBL4649999 | 0.78 | TLR9 (0.54) | — | |
| SCHEMBL4650745 | 0.78 | HTR6 (0.47) | — | |
| SCHEMBL7364566 | 0.78 | CHRNB2 (0.78) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730112-B1 | 3-((HETERO)ARYLSULFONYL)-8'[ (AMINOALKYL)OXY]QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | claimed |