Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650016 | 0.94 | PRKCZ (0.49) | ROCK1ROCK2KCNH2CHRNB2CHRNA4 | |
| SCHEMBL4649415 | 0.87 | ROCK1 (0.46) | ROCK1ROCK2PRKCDPRKCZIKBKB | |
| SCHEMBL4649412 | 0.80 | CHRM2 (0.45) | ROCK1ROCK2KCNH2HTR2AHTR6 | |
| SCHEMBL4649236 | 0.80 | HTR1A (0.52) | ROCK1ROCK2KCNH2CHRNB2CHRNA4 | |
| SCHEMBL4650745 | 0.79 | HTR6 (0.47) | HTR2AHTR6 | |
| SCHEMBL4650006 | 0.78 | HTR6 (0.44) | CHEK2HTR2AHTR6ALK | |
| SCHEMBL4650101 | 0.78 | HTR6 (0.44) | CHEK2HTR2AHTR6ALK | |
| SCHEMBL4650621 | 0.78 | LTA4H (0.48) | CHRNB2CHRNA4 | |
| SCHEMBL4649974 | 0.73 | CHRM2 (0.43) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL4649235 | 0.73 | CHRM2 (0.43) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730112-B1 | 3-((HETERO)ARYLSULFONYL)-8'[ (AMINOALKYL)OXY]QUINOLINES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | claimed |