Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MDH2 | P40926 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649998 | 0.90 | RAB9A (0.41) | ALDH1A1LMNAMDH2HPGDSMN1; SMN2 | |
| SCHEMBL4650809 | 0.87 | PRKAB2 (0.47) | ALDH1A1LMNAMDH2HPGDSMN1; SMN2 | |
| SCHEMBL4649277 | 0.85 | ALDH1A1 (0.41) | ALDH1A1LMNAMDH2HPGDSMN1; SMN2 | |
| SCHEMBL4649447 | 0.84 | RAB9A (0.49) | ALDH1A1LMNAMDH2HPGDSMN1; SMN2 | |
| SCHEMBL4650041 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNAHPGDKDM4ECYP1A2 | |
| SCHEMBL4650793 | 0.81 | ALDH1A1 (0.46) | ALDH1A1LMNAMDH2HPGDSMN1; SMN2 | |
| SCHEMBL4650802 | 0.81 | ALDH1A1 (0.53) | ALDH1A1LMNAHPGDKDM4ECYP1A2 | |
| SCHEMBL4650139 | 0.81 | ALDH1A1 (0.51) | ALDH1A1LMNAMDH2HPGDSMN1; SMN2 | |
| SCHEMBL4650110 | 0.78 | KDM5A (0.42) | ALDH1A1LMNAMDH2HPGDSMN1; SMN2 | |
| SCHEMBL4649211 | 0.78 | ALDH1A1 (0.49) | ALDH1A1LMNAMDH2HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | claimed |