Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652792 | 0.86 | CCR2 (0.49) | CCR2TP53MAPTPLA2G2A | |
| SCHEMBL4649957 | 0.80 | CCR2 (0.53) | CCR2MAPTPLA2G2AF10 | |
| SCHEMBL4649840 | 0.80 | CCR2 (0.52) | CCR2TP53MAPTPLA2G2AF10 | |
| SCHEMBL4650663 | 0.80 | CCR2 (0.55) | CCR2MAPTPLA2G2AF10 | |
| SCHEMBL4650169 | 0.78 | CCR9 (0.55) | CCR2 | |
| SCHEMBL4648818 | 0.76 | CCR2 (0.53) | CCR2MAPTF10 | |
| SCHEMBL4650004 | 0.76 | CCR2 (0.54) | CCR2MAPTPLA2G2AF10 | |
| SCHEMBL4748723 | 0.76 | PTGES (0.51) | CCR2PLA2G2A | |
| SCHEMBL4807606 | 0.74 | CCR2 (0.51) | CCR2MAPTF10 | |
| SCHEMBL4649909 | 0.74 | CCR2 (0.50) | CCR2MAPTF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904487-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006067392-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF TUBERCULOSIS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |