Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | GABRP | O00591 | 12/20 | 0.80 |
| ▸ | GABRD | O14764 | 12/20 | 0.80 |
| ▸ | GABRA1 | P14867 | 12/20 | 0.80 |
| ▸ | GABRB1 | P18505 | 12/20 | 0.80 |
| ▸ | GABRG2 | P18507 | 12/20 | 0.80 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.80 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.80 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.80 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.80 |
| ▸ | GABRB2 | P47870 | 12/20 | 0.80 |
| ▸ | GABRA4 | P48169 | 12/20 | 0.80 |
| ▸ | GABRE | P78334 | 12/20 | 0.80 |
| ▸ | GABRA6 | Q16445 | 12/20 | 0.80 |
| ▸ | GABRG1 | Q8N1C3 | 12/20 | 0.80 |
| ▸ | GABRG3 | Q99928 | 12/20 | 0.80 |
| ▸ | GABRQ | Q9UN88 | 12/20 | 0.80 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.73 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 6-Chloroflavone SCHEMBL7030912 | 0.93 | TNKS (0.86) | TNKSADORA3GABRPGABRDGABRA1 | |
| SCHEMBL4650588 | 0.90 | GABRP (0.82) | TNKSADORA3GABRPGABRDGABRA1 | |
| 7-Chloroflavone SCHEMBL12940670 | 0.87 | TNKS (0.77) | TNKSADORA3GABRPGABRDGABRA1 | |
| SCHEMBL12941631 | 0.84 | NPC1 (0.77) | TNKSADORA3GABRPGABRDGABRA1 | |
| SCHEMBL24227286 | 0.83 | PLA2G2A (0.97) | TNKSADORA3GABRPGABRDGABRA1 | |
| SCHEMBL28100458 | 0.82 | PLA2G2A (0.76) | TNKSADORA3GABRPGABRDGABRA1 | |
| SCHEMBL30000854 | 0.82 | TNKS (0.69) | TNKSADORA3GABRPGABRDGABRA1 | |
| SCHEMBL4650655 | 0.82 | TNKS (1.00) | TNKSADORA3GABRPGABRDGABRA1 | |
| SCHEMBL6907832 | 0.81 | GABRP (0.74) | TNKSADORA3GABRPGABRDGABRA1 | |
| Flavone SCHEMBL18879 | 0.81 | TNKS (1.00) | TNKSADORA3GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | claimed |
| EP-2730431-B1 | Rubber composition and tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2015129813-A1 | DEUTERATION METHOD AND DEUTERATION CATALYST | 国立大学法人 長崎大学 | 2015-09-03 | — | — | WO | disclosed |
| US-20140135433-A1 | TIRE WITH RUBBER CONTAINING FLAVONE | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2014-05-15 | — | — | US | disclosed |
| EP-2730431-A1 | Rubber composition and tire with rubber containing flavone | The Goodyear Tire & Rubber Company (US) | 2014-05-14 | — | — | EP | disclosed |
| CN-102140087-B | Synthetic method for chromone compound | UNIV TSINGHUA | 2013-02-13 | — | — | CN | disclosed |
| US-20110230523-A1 | TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | PARATEK PHARMACEUTICALS, INC. (US) | 2011-09-22 | — | — | US | disclosed |
| CN-102140087-A | Synthetic method for chromone compound | UNIV TSINGHUA | 2011-08-03 | — | — | CN | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| EP-1391327-B1 | Tire with rubber containing flavone | GOODYEAR TIRE & RUBBER (US) | 2008-09-03 | — | — | EP | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-6872771-B1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2005-03-29 | — | — | US | disclosed |
| EP-1391327-A1 | Tire with rubber containing flavone | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2004-02-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | JUN, CREBBP, TFEB | TNKS 1140/4885ADORA3 4693/4885GABRP 1579/4885 |
| US-20110230523-A1 | TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | JUN, CREBBP, TFEB | TNKS 1140/4885ADORA3 4693/4885GABRP 1579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.