SCHEMBL4651682

SCHEMBL4651682

O=C1c2ccccc2C(=O)N1CCc1cscn1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.60
PKM P14618 2/20 0.57
MAPT P10636 3/20 0.56
POLB P06746 2/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
ALDH1A1 P00352 3/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
LMNA P02545 3/20 0.51
L3MBTL1 Q9Y468 3/20 0.50
HPGD P15428 1/20 0.50
GLS O94925 1/20 0.49
RXFP1 Q9HBX9 1/20 0.47
CASP3 P42574 1/20 0.46
TSHR P16473 1/20 0.46
PDE10A Q9Y233 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29451773 1.00 HSD17B10 (0.60) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL1190831 0.84 PKM (0.58) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL2908032 0.78 PKM (0.51) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL3281437 0.76 HSD17B10 (1.00) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL23027798 0.75 LMNA (0.78) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL17261495 0.74 PKM (0.72) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL1786217 0.73 HSD17B10 (0.62) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL29451720 0.73 PKM (0.70) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL4604023 0.73 PKM (0.70) HSD17B10PKMMAPTPOLBMEN1
SCHEMBL6123101 0.73 GRM5 (0.44) HSD17B10PKMMAPTPOLBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3960171-B1 USE OF ADAM9 INHIBITOR AS IMMUNOMODULATOR UNIV CHINA MEDICAL (TW) 2025-01-01 EP claimed
US-20220202783-A1 Use Of ADAM9 Inhibitor As Immunomodulator CHINA MEDICAL UNIVERSITY (TW) 2022-06-30 US claimed
US-11357759-B2 Composition including ADAM9 inhibitor and the use thereof CHINA MEDICAL UNIVERSITY (TW) 2022-06-14 US claimed
CN-114173778-A Use of ADAM9 inhibitors as immunomodulators 洪明奇 2022-03-11 CN claimed
EP-3960171-A1 USE OF ADAM9 INHIBITOR AS IMMUNOMODULATOR China Medical University (TW) 2022-03-02 EP claimed
US-20210052562-A1 Composition Including ADAM9 Inhibitor And The Use Thereof CHINA MEDICAL UNIVERSITY (TW) 2021-02-25 US claimed
WO-2020216319-A1 USE OF ADAM9 INHIBITOR AS IMMUNOMODULATOR 中国医药大学 2020-10-29 WO claimed
CN-111655256-A ADAM9 inhibitors and uses thereof 中国医药大学 2020-09-11 CN claimed
EP-3700521-A1 ADAM9 inhibitors and the uses thereof China Medical University (TW) 2020-09-02 EP claimed
EP-3960171-B1 USE OF ADAM9 INHIBITOR AS IMMUNOMODULATOR UNIV CHINA MEDICAL (TW) 2025-01-01 EP disclosed
CN-114173778-B Application of ADAM9 inhibitor in preparation of medicines for preparing immunomodulators 洪明奇 2024-12-27 CN disclosed
US-20220202783-A1 Use Of ADAM9 Inhibitor As Immunomodulator CHINA MEDICAL UNIVERSITY (TW) 2022-06-30 US disclosed
CN-114173778-A Use of ADAM9 inhibitors as immunomodulators 洪明奇 2022-03-11 CN disclosed
EP-3960171-A1 USE OF ADAM9 INHIBITOR AS IMMUNOMODULATOR China Medical University (TW) 2022-03-02 EP disclosed
EP-3700521-A1 ADAM9 inhibitors and the uses thereof China Medical University (TW) 2020-09-02 EP disclosed
EP-1644320-B1 INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS LILLY CO ELI (US) 2008-01-16 EP disclosed
US-7265246-B2 Indane derivates as muscarinic receptor agonists ELI LILLY AND COMPANY (US) 2007-09-04 US disclosed
US-20070060587-A1 Indane derivates as muscarinic receptor agonists ELI LILLY AND COMPANY (US) 2007-03-15 US disclosed
EP-1644320-A1 INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2006-04-12 EP disclosed
WO-2005009941-A1 INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2005-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11357759-B2 Composition including ADAM9 inhibitor and the use thereof ADAM9, ADAM8, ADAM17 HSD17B10 247/4885PKM 2653/4885MAPT 1737/4885
US-20220202783-A1 Use Of ADAM9 Inhibitor As Immunomodulator ADAM9, ADAM17, ADAM10 HSD17B10 630/4885PKM 3832/4885MAPT 3674/4885
US-20070060587-A1 Indane derivates as muscarinic receptor agonists CHRM1, CHRM3, CHRM2 HSD17B10 2457/4885PKM 2682/4885MAPT 2820/4885
US-20210052562-A1 Composition Including ADAM9 Inhibitor And The Use Thereof ADAM9, ADAM8, ADAM17 HSD17B10 247/4885PKM 2653/4885MAPT 1737/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.