Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 8/20 | 0.55 |
| ▸ | CA2 | P00918 | 8/20 | 0.55 |
| ▸ | CA9 | Q16790 | 8/20 | 0.55 |
| ▸ | CA1 | P00915 | 7/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.54 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820777 | 0.84 | LMNA (0.46) | CA12CA2CA9CA1CA14 | |
| SCHEMBL569758 | 0.81 | SOS1 (0.55) | CA12CA2CA9CA1CA14 | |
| SCHEMBL3717532 | 0.79 | CA12 (0.47) | CA12CA2CA9CA1CA14 | |
| SCHEMBL10529086 | 0.77 | CA2 (0.54) | CA12CA2CA9CA1CA14 | |
| SCHEMBL11478665 | 0.75 | LMNA (0.53) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL5318974 | 0.75 | LMNA (0.53) | CA2CA1LMNATDP1ALDH1A1 | |
| SCHEMBL5332097 | 0.75 | LMNA (0.53) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL32664452 | 0.75 | HTR1A (0.55) | CA12CA2CA9CA1CA14 | |
| SCHEMBL10622816 | 0.75 | HTR1A (0.55) | CA12CA2CA9CA1CA14 | |
| SCHEMBL3717535 | 0.73 | ALDH1A1 (0.62) | LMNATDP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999121-A1 | NOVEL TETRALINS AS 5-HT6 MODULATORS | AstraZeneca AB (SE) | 2008-12-10 | — | — | EP | claimed |
| WO-2007108742-A1 | NOVEL TETRALINS AS 5-HT6 MODULATORS | ASTRAZENECA AB (SE) | 2007-09-27 | — | — | WO | claimed |
| EP-1999121-A1 | NOVEL TETRALINS AS 5-HT6 MODULATORS | AstraZeneca AB (SE) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007108742-A1 | NOVEL TETRALINS AS 5-HT6 MODULATORS | ASTRAZENECA AB (SE) | 2007-09-27 | — | — | WO | disclosed |