Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657761 | 0.82 | HRH3 (0.52) | MEN1KMT2A | |
| SCHEMBL4658054 | 0.81 | CCR3 (0.60) | CARM1PRMT6TSHR | |
| SCHEMBL18284744 | 0.79 | DRD2 (0.58) | DRD2DRD4DRD3SLC18A3MEN1 | |
| SCHEMBL4658921 | 0.78 | LSS (0.48) | DRD2DRD4DRD3GRM2SLC18A3 | |
| SCHEMBL5201188 | 0.76 | SIGMAR1 (0.52) | DRD2DRD4DRD3GRM2SLC18A3 | |
| SCHEMBL22561509 | 0.72 | CYP2A13 (0.49) | MEN1KMT2ATP53 | |
| SCHEMBL1002852 | 0.72 | MEN1 (0.81) | DRD2DRD4DRD3SLC18A3MEN1 | |
| SCHEMBL3399715 | 0.71 | DRD2 (1.00) | DRD2DRD4DRD3SLC18A3MEN1 | |
| SCHEMBL3313308 | 0.70 | HTR7 (0.49) | DRD2SLC18A3MEN1KMT2ACARM1 | |
| SCHEMBL1003503 | 0.70 | DRD2 (0.73) | DRD2DRD4DRD3SLC18A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753757-B1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2008-12-10 | — | — | EP | claimed |
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | claimed |
| EP-1753757-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2007-02-21 | — | — | EP | claimed |
| WO-2005113549-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | claimed |
| EP-1753757-B1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | GRUENENTHAL GMBH (DE) | 2008-12-10 | — | — | EP | disclosed |
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | disclosed |
| EP-1753757-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113549-A1 | SUBSTITUTED 2,5-DIAMINOMETHYL-1H-PYRROLES | Grünenthal GmbH (DE) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135403-A1 | Substituted 2,5-diaminomethyl-1H-pyrrole compounds | OPRL1, OPRK1, OPRM1 | DRD2 55/4885DRD4 95/4885DRD3 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.