SCHEMBL4659351

SCHEMBL4659351

O=C(CNC(=O)O)Cc1ccoc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.40
TSHR P16473 1/20 0.40
SLC1A3 P43003 1/20 0.38
SLC1A2 P43004 1/20 0.38
SLC1A1 P43005 1/20 0.38
FAAH O00519 2/20 0.37
CNR2 P34972 2/20 0.37
ALDH1A1 P00352 2/20 0.37
MEN1 O00255 1/20 0.37
MAPT P10636 1/20 0.37
RECQL P46063 1/20 0.37
BLM P54132 1/20 0.37
KMT2A Q03164 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
HCAR2 Q8TDS4 1/20 0.36
HCAR3 P49019 1/20 0.35
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
TAS2R8 Q9NYW2 1/20 0.34
OPRM1 P35372 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27599213 0.80 ALOX5 (0.43) ALOX5TSHRSLC1A3SLC1A2SLC1A1
SCHEMBL1295536 0.77 EPHX2 (0.38) TSHRFAAHCNR2ALDH1A1MEN1
SCHEMBL11623673 0.76 ALDH1A1 (0.47) ALOX5TSHRSLC1A3SLC1A2SLC1A1
SCHEMBL4582402 0.76 CES1 (0.52) TSHRALDH1A1MEN1KMT2ATDP1
SCHEMBL3878505 0.75
SCHEMBL9868561 0.75
SCHEMBL10449720 0.74 ALOX5 (0.44) ALOX5TSHRSLC1A3SLC1A2SLC1A1
SCHEMBL11337456 0.74 ALOX5 (0.44) ALOX5TSHRSLC1A3SLC1A2SLC1A1
SCHEMBL27583227 0.74 ALOX5 (0.44) ALOX5TSHRSLC1A3SLC1A2SLC1A1
SCHEMBL4659431 0.73 L3MBTL1 (0.54) ALDH1A1MEN1MAPTKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2004166-A2 INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES LA JOLLA PHARMACEUTICAL COMPANY (US) 2008-12-24 EP disclosed
WO-2007120528-A2 INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES LA JOLLA PHARMACEUTICAL COMPANY (US) 2007-10-25 WO disclosed