Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527957 | 0.84 | CES2 (0.48) | CES1CES2AKR1B1MEN1KMT2A | |
| SCHEMBL4659431 | 0.84 | L3MBTL1 (0.54) | MEN1KMT2ATDP1L3MBTL1HPGD | |
| SCHEMBL7965958 | 0.82 | RAB9A (0.51) | KMT2ATDP1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4659306 | 0.82 | KMT2A (0.50) | MEN1KMT2ATDP1L3MBTL1CYP1A2 | |
| SCHEMBL4659414 | 0.82 | CTBP2 (0.54) | MEN1KMT2AL3MBTL1HPGDALDH1A1 | |
| SCHEMBL24487008 | 0.81 | CES2 (0.45) | CES1CES2AKR1B1MEN1KMT2A | |
| SCHEMBL5150815 | 0.81 | HDAC8 (0.57) | CES1CES2AKR1B1MEN1KMT2A | |
| SCHEMBL4660680 | 0.81 | RAB9A (0.49) | ALDH1A1RAB9A | |
| SCHEMBL10962854 | 0.80 | VNN1 (0.56) | CES1CES2AKR1B1MEN1KMT2A | |
| SCHEMBL51367 | 0.80 | CES1 (0.64) | CES1CES2AKR1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |