Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GNRHR | P30968 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17775886 | 0.91 | P2RX3 (0.60) | KMT2APOLBP2RX3ALDH1A1KDM4E | |
| SCHEMBL4659687 | 0.87 | LMNA (0.51) | POLBALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL11398510 | 0.86 | KMT2A (0.60) | KMT2APOLBP2RX3ALDH1A1KDM4E | |
| SCHEMBL11067835 | 0.86 | KMT2A (0.60) | KMT2APOLBP2RX3ALDH1A1KDM4E | |
| SCHEMBL8041564 | 0.84 | POLB (0.69) | KMT2APOLBP2RX3ALDH1A1KDM4E | |
| SCHEMBL29823822 | 0.84 | POLB (0.69) | KMT2APOLBP2RX3ALDH1A1KDM4E | |
| SCHEMBL7035140 | 0.83 | KMT2A (0.57) | KMT2APOLBP2RX3ALDH1A1KDM4E | |
| SCHEMBL20577692 | 0.82 | KMT2A (0.48) | KMT2APOLBP2RX3ALDH1A1KDM4E | |
| SCHEMBL7041173 | 0.82 | KMT2A (0.56) | KMT2APOLBP2RX3ALDH1A1KDM4E | |
| SCHEMBL31513796 | 0.82 | NPC1 (0.60) | KMT2APOLBP2RX3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503759-B1 | SUBSTITUTED QUINOLONE CARBOXYLIC ACIDS, THEIR DERIVATIVES, SITE OF ACTION, AND USES THEREOF | UNIV CALIFORNIA (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20080176897-A1 | Substituted Quinolone Carboxylic Acids, Their Derivatives, Site of Action, And Uses Thereof | JOHNSTONE TIMOTHY B C | 2008-07-24 | — | — | US | disclosed |
| US-7355047-B2 | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-04-08 | — | — | US | disclosed |
| US-20060178516-A1 | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof | OXFORD FINANCE CORPORATION | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178516-A1 | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof | GABRB2, GABRB1, GABRB3 | KMT2A 2709/4885POLB 2636/4885P2RX3 431/4885 |
| US-20080176897-A1 | Substituted Quinolone Carboxylic Acids, Their Derivatives, Site of Action, And Uses Thereof | GABRB2, GABRB1, GABRB3 | KMT2A 2709/4885POLB 2636/4885P2RX3 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.