Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427624 | 0.86 | TDP1 (0.37) | KIF11TDP1CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL19064319 | 0.78 | KIF11 (0.38) | KIF11CYP2C19CYP1A2CYP2C9CHRM4 | |
| SCHEMBL4194598 | 0.78 | KIF11 (0.38) | KIF11CHRM4CHRM5CHRM3CHRM2 | |
| SCHEMBL6551716 | 0.77 | KIF11 (0.61) | KIF11CYP2C19CYP2C9CHRM4CHRM5 | |
| Ammonia Solution, Strong SCHEMBL2922340 | 0.76 | KIF11 (0.59) | KIF11CYP2C19CYP2C9CHRM4CHRM5 | |
| SCHEMBL7453762 | 0.76 | KIF11 (0.59) | KIF11CYP2C19CYP2C9CHRM4CHRM5 | |
| SCHEMBL2006125 | 0.76 | CHRM4 (0.56) | KIF11CHRM4CHRM5CHRM3CHRM2 | |
| SCHEMBL29214644 | 0.75 | SIGMAR1 (0.40) | SIGMAR1HTR2AKCNH2 | |
| SCHEMBL9172236 | 0.74 | KIF11 (0.57) | KIF11CYP2C19CYP2C9CHRM4CHRM5 | |
| SCHEMBL8310962 | 0.74 | CHRM3 (0.39) | KIF11TDP1CYP2C19CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444239-B1 | HIGH REFRACTIVE INDEX AROMATIC-BASED SILYL MONOMERS | BAUSCH & LOMB (US) | 2008-12-24 | — | — | EP | disclosed |
| US-7132494-B2 | High refractive index aromatic-based silyl monomers | BAUSCH & LOMB INCORPORATED (US) | 2006-11-07 | — | — | US | disclosed |
| US-6881809-B2 | High refractive index aromatic-based silyl monomers | BAUSCH & LOMB INCORPORATED (US) | 2005-04-19 | — | — | US | disclosed |
| US-6846897-B2 | High refractive index aromatic-based silyl monomers | BAUSCH AND LOMB, INC. (US) | 2005-01-25 | — | — | US | disclosed |
| US-20040230023-A1 | High refractive index aromatic-based silyl monomers | SALAMONE JOSEPH C (US) | 2004-11-18 | — | — | US | disclosed |
| US-20040215156-A1 | High refractive index aromatic-based silyl monomers | SOLTA MEDICAL, INC. | 2004-10-28 | — | — | US | disclosed |
| US-20040215032-A1 | High refractive index aromatic-based silyl monomers | SALAMONE JOSEPH C | 2004-10-28 | — | — | US | disclosed |
| US-20040210023-A1 | High refractive index aromatic-based silyl monomers | SALAMONE JOSEPH C (US) | 2004-10-21 | — | — | US | disclosed |
| EP-1444239-A1 | HIGH REFRACTIVE INDEX AROMATIC-BASED SILYL MONOMERS | BAUSCH & LOMB INCORPORATED (US) | 2004-08-11 | — | — | EP | disclosed |
| US-6762271-B2 | INTRAOCULAR LENSES, CONTACT LENSES AND CORNEAL INLAYS | BAUSCH & LOMB INCORPORATED | 2004-07-13 | — | — | US | disclosed |
| US-20030105255-A1 | High refractive index aromatic-based silyl monomers | BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC. (CA) | 2003-06-05 | — | — | US | disclosed |
| WO-2003040152-A1 | HIGH REFRACTIVE INDEX AROMATIC-BASED SILYL MONOMERS | BAUSCH & LOMB INCORPORATED (US) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040215032-A1 | High refractive index aromatic-based silyl monomers | SMAD2, SMAD3, FHIT | KIF11 1305/4885KCNH3 1604/4885TDP1 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.