Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.42 |
| ▸ | HTR1A | P08908 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | DRD4 | P21917 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.42 |
| ▸ | HTR2C | P28335 | 6/20 | 0.42 |
| ▸ | HTR7 | P34969 | 6/20 | 0.42 |
| ▸ | HTR1D | P28221 | 5/20 | 0.42 |
| ▸ | HRH2 | P25021 | 5/20 | 0.42 |
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | DRD1 | P21728 | 4/20 | 0.40 |
| ▸ | DRD5 | P21918 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664225 | 0.84 | OPRL1 (0.49) | OPRL1OPRM1OPRK1HTR1ADRD2 | |
| SCHEMBL4665755 | 0.79 | OPRM1 (0.45) | OPRL1OPRM1DRD4DRD3SLC6A2 | |
| SCHEMBL4665356 | 0.79 | OPRL1 (0.46) | OPRL1OPRM1OPRK1HTR1ADRD2 | |
| SCHEMBL156982 | 0.79 | MAOB (0.42) | OPRL1OPRM1OPRK1OPRD1SLC6A2 | |
| SCHEMBL29025309 | 0.79 | MAOB (0.42) | OPRL1OPRM1OPRK1OPRD1SLC6A2 | |
| SCHEMBL4665563 | 0.78 | OPRM1 (0.46) | OPRL1OPRM1SLC6A4SLC6A3CCR2 | |
| SCHEMBL4664216 | 0.74 | OPRM1 (0.45) | OPRL1OPRM1OPRK1OPRD1HDAC4 | |
| SCHEMBL4664156 | 0.73 | GRIN2B (0.40) | OPRL1OPRM1OPRK1HTR1ADRD2 | |
| SCHEMBL4665390 | 0.71 | OPRK1 (0.44) | OPRL1OPRM1OPRK1HTR1ADRD2 | |
| SCHEMBL4663683 | 0.69 | SLC6A4 (0.41) | OPRM1OPRK1OPRD1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1571140-B1 | C-substituted cyclohexylmethylamine derivatives | GRUENENTHAL GMBH (DE) | 2008-11-12 | — | — | EP | claimed |