Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | ETV6 | P41212 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304196 | 0.88 | L3MBTL3 (0.41) | HSP90AA1KCNH2L3MBTL3L3MBTL1FAAH | |
| SCHEMBL4771706 | 0.83 | AXL (0.37) | HSP90AA1KCNH2FYNL3MBTL3L3MBTL1 | |
| SCHEMBL4142789 | 0.81 | HTR7 (0.41) | FAAHHTR1D | |
| SCHEMBL4137087 | 0.78 | HTR1D (0.41) | FYNL3MBTL3L3MBTL1FAAHHTR1D | |
| SCHEMBL4135754 | 0.76 | HRH3 (0.42) | L3MBTL3FAAHHRH3 | |
| SCHEMBL4140115 | 0.76 | TDP2 (0.45) | L3MBTL3L3MBTL1FAAHHTR1DHRH3 | |
| SCHEMBL4144270 | 0.76 | TDP2 (0.45) | L3MBTL3L3MBTL1FAAHHTR1DHRH3 | |
| SCHEMBL4140118 | 0.76 | TDP2 (0.45) | L3MBTL3L3MBTL1FAAHHTR1DHRH3 | |
| SCHEMBL4144848 | 0.74 | ALDH1A1 (0.39) | HTR1DHRH3 | |
| SCHEMBL4132414 | 0.74 | HRH3 (0.45) | L3MBTL3L3MBTL1FAAHHTR1DHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007749-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | Pfizer Products Inc. (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007105053-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | disclosed |