Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL4908574 | 0.98 | ESR1 (0.36) | ESR1ESR2HTTALOX15NPC1 | |
| SCHEMBL16217689 | 0.81 | ALDH1A1 (0.38) | ESR1ESR2HTTSMN1; SMN2ADRA2A | |
| SCHEMBL19621808 | 0.78 | ESR1 (0.35) | ESR1ESR2HTTSMN1; SMN2RAB9A | |
| SCHEMBL16229870 | 0.78 | ADRA2A (0.58) | ESR1ESR2HTTALOX15NPC1 | |
| SCHEMBL16217691 | 0.77 | ESR1 (0.34) | ESR1ESR2HTTSMN1; SMN2LMNA | |
| SCHEMBL29739702 | 0.73 | PLAU (0.37) | ESR1ESR2HTTALOX15NPC1 | |
| SCHEMBL30058583 | 0.71 | ESR1 (0.30) | ESR1ESR2 | |
| SCHEMBL986215 | 0.69 | ESR2 (0.68) | ESR1ESR2NPC1RAB9APLAU | |
| SCHEMBL1260386 | 0.69 | CCNE1 (0.37) | ESR1ESR2HTTALOX15NPC1 | |
| SCHEMBL31631912 | 0.67 | ALDH1A1 (0.38) | ESR1ESR2HTTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994472-B1 | PROCESS FOR THE PREPARATION OF BORONIC ACID INTERMEDIATES | HOFFMANN LA ROCHE (CH) | 2017-11-22 | — | — | EP | disclosed |
| EP-2994472-B1 | PROCESS FOR THE PREPARATION OF BORONIC ACID INTERMEDIATES | HOFFMANN LA ROCHE (CH) | 2017-11-22 | — | — | EP | disclosed |
| EP-2994472-A1 | PROCESS FOR THE PREPARATION OF BORONIC ACID INTERMEDIATES | F. Hoffmann-La Roche AG (CH) | 2016-03-16 | — | — | EP | disclosed |
| EP-1988095-B1 | Method for manufacturing aminoaryl or heteroaryl boronic acid and their derivatives | EUTICALS GMBH (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-9102689-B2 | Process for the preparation of boronic acid intermediates | HOFFMANN-LA ROCHE INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-9102689-B2 | Process for the preparation of boronic acid intermediates | HOFFMANN-LA ROCHE INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-9102689-B2 | Process for the preparation of boronic acid intermediates | HOFFMANN-LA ROCHE INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20140330008-A1 | PROCESS FOR THE PREPARATION OF BORONIC ACID INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140330008-A1 | PROCESS FOR THE PREPARATION OF BORONIC ACID INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20140330008-A1 | PROCESS FOR THE PREPARATION OF BORONIC ACID INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2014-11-06 | — | — | US | disclosed |
| EP-1988095-A2 | Method for manufacturing aminoaryl or heteroaryl boronic acid and their derivatives | Archimica GmbH (DE) | 2008-11-05 | — | — | EP | disclosed |
| US-20080269523-A1 | Preparation of Aminoaryl and Aminoheteroaryl Boronic Acids and Derivatives Thereof | ARCHIMICA GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269523-A1 | Preparation of Aminoaryl and Aminoheteroaryl Boronic Acids and Derivatives Thereof | BCAT1, BCAT2, AADAT | ESR1 2053/4885ESR2 2415/4885HTT 1562/4885 |
| US-20140330008-A1 | PROCESS FOR THE PREPARATION OF BORONIC ACID INTERMEDIATES | BCAT1, SLC1A5, BCAT2 | ESR1 1435/4885ESR2 2227/4885HTT 4084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.