Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CALM1 | P0DP23 | 3/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38656636 | 0.86 | CYP4F2 (0.38) | ALDH1A1CYP19A1CALM1TSHRPTGS2 | |
| SCHEMBL1006647 | 0.79 | TAAR1 (0.55) | — | |
| SCHEMBL2390804 | 0.77 | ALDH1A1 (0.50) | ALDH1A1CYP19A1CALM1AKR1B1CYP1A1 | |
| SCHEMBL363725 | 0.77 | IDO1 (0.52) | ALDH1A1CALM1TSHR | |
| SCHEMBL627823 | 0.73 | ALDH1A1 (0.58) | ALDH1A1CYP19A1CALM1AKR1B1CYP1A1 | |
| SCHEMBL9491787 | 0.72 | CYP19A1 (0.68) | ALDH1A1CYP19A1CALM1AKR1B1CYP1A1 | |
| SCHEMBL5252553 | 0.72 | ALDH1A1 (0.65) | ALDH1A1CYP19A1CALM1AKR1B1CYP1A1 | |
| SCHEMBL467237 | 0.71 | ALDH1A1 (0.55) | ALDH1A1CYP19A1CALM1AKR1B1CYP1A1 | |
| 1,3,5-Trimethoxybenzene SCHEMBL28493 | 0.71 | ALDH1A1 (1.00) | ALDH1A1CYP19A1CYP1A1CYP1B1PTGS2 | |
| SCHEMBL88823 | 0.70 | ALDH1A1 (0.61) | ALDH1A1CYP19A1CALM1AKR1B1CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579438-B | Compounds and methods for skin repair | 阿勒根公司 | 2019-12-06 | — | — | CN | disclosed |
| US-9546162-B2 | Compounds and methods for skin repair | ALLERGAN, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| EP-3049392-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN, INC. (US) | 2016-08-03 | — | — | EP | disclosed |
| US-20150094330-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN INC (US) | 2015-04-02 | — | — | US | disclosed |
| WO-2015048553-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | ALLERGAN, INC. (US) | 2015-04-02 | — | — | WO | disclosed |
| EP-2399577-A1 | Use of N-containing spirocompounds for the enhancement of cognitive function | Adolor Corporation (US) | 2011-12-28 | — | — | EP | disclosed |
| US-8022060-B2 | Spirocyclic heterocyclic derivatives and methods of their use | ADOLOR CORPORATION (US) | 2011-09-20 | — | — | US | disclosed |
| US-20110218186-A1 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2011-09-08 | — | — | US | disclosed |
| US-20100029614-A1 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
| US-7598261-B2 | Spirocyclic heterocyclic derivatives and methods of their use | ADOLOR CORPORATION (US) | 2009-10-06 | — | — | US | disclosed |
| US-20080119452-A1 | METHODS FOR ENHANCING COGNITIVE FUNCTION | CALIXA THERAPEUTICS, INC. | 2008-05-22 | — | — | US | disclosed |
| WO-2008033299-A2 | USE OF N-CONTAINING SPIROCOMPOUNDS FOR THE ENHANCEMENT OF COGNITIVE FUNCTION | ADOLOR CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |
| EP-1871761-A2 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | Adolor Corporation (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20060270695-A1 | Spirocyclic heterocyclic derivatives and methods of their use | CUBIST PHARMACEUTICALS, INC. | 2006-11-30 | — | — | US | disclosed |
| WO-2006105442-A2 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |
| US-20050239874-A1 | Novel analgesic and immunomodulatory cannabinoids | UNIVERSITY OF CONNECTICUT (US) | 2005-10-27 | — | — | US | disclosed |
| US-6939977-B2 | Analgesic and immunomodulatory cannabinoids | THE UNIVERSITY OF CONNECTICUT (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1075470-B1 | NOVEL ANALGESIC AND IMMUNOMODULATORY CANNABINOIDS | UNIV CONNECTICUT (US) | 2003-08-13 | — | — | EP | disclosed |
| US-20030120094-A1 | For improved binding of CB1/CB2 receptors; side effects reduction | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-06-26 | — | — | US | disclosed |
| US-20010009965-A1 | NOVEL ANALGESIC AND IMMUNOMODULATORY CANNABINOIDS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2001-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218186-A1 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | OPRK1, OPRD1, OPRL1 | ALDH1A1 259/4885CYP19A1 711/4885CALM1 1251/4885 |
| US-20150094330-A1 | COMPOUNDS AND METHODS FOR SKIN REPAIR | PTGER4, LTB4R2, LTB4R | ALDH1A1 600/4885CYP19A1 1875/4885CALM1 3180/4885 |
| US-20080119452-A1 | METHODS FOR ENHANCING COGNITIVE FUNCTION | CHAT, GRIN2C, GRIN2A | ALDH1A1 1162/4885CYP19A1 1406/4885CALM1 391/4885 |
| US-20100029614-A1 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | OPRK1, OPRD1, OPRL1 | ALDH1A1 259/4885CYP19A1 711/4885CALM1 1251/4885 |
| US-20060270695-A1 | Spirocyclic heterocyclic derivatives and methods of their use | OPRK1, OPRD1, OPRL1 | ALDH1A1 259/4885CYP19A1 711/4885CALM1 1251/4885 |
| US-20010009965-A1 | NOVEL ANALGESIC AND IMMUNOMODULATORY CANNABINOIDS | CNR1, CNR2, CHRNA1 | ALDH1A1 2733/4885CYP19A1 920/4885CALM1 152/4885 |
| US-20030120094-A1 | For improved binding of CB1/CB2 receptors; side effects reduction | CNR1, CNR2, CHRNA1 | ALDH1A1 4204/4885CYP19A1 937/4885CALM1 240/4885 |
| US-20050239874-A1 | Novel analgesic and immunomodulatory cannabinoids | CNR1, CNR2, NPY1R | ALDH1A1 2172/4885CYP19A1 868/4885CALM1 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.