Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300285 | 0.84 | NPC1 (0.41) | HRH3DRD2DRD3POLB | |
| SCHEMBL6300283 | 0.80 | PARP10 (0.47) | HRH3KMT2AMEN1 | |
| SCHEMBL4672086 | 0.77 | KCNJ1 (0.53) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4670082 | 0.76 | KMT2A (0.48) | MAPTPKMSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4670425 | 0.75 | KMT2A (0.43) | MAPTPKMSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28180201 | 0.75 | HSPB1 (0.66) | MAPTGAAHSPB1HRH3KMT2A | |
| SCHEMBL28180988 | 0.75 | HSPB1 (0.70) | ENPP2MAPTGAAHSPB1HRH3 | |
| SCHEMBL4673671 | 0.74 | SIGMAR1 (0.52) | MAPTPKMSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4672275 | 0.73 | ALDH1A1 (0.44) | MAPTPKMSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4675267 | 0.72 | ALDH1A1 (0.41) | MAPTPKMSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |