Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673671 | 0.85 | SIGMAR1 (0.52) | KCNJ1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4672126 | 0.84 | NPBWR1 (0.42) | MAPTSMN1; SMN2MAPK1LMNA | |
| SCHEMBL4670082 | 0.77 | KMT2A (0.48) | MAPTSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL4670425 | 0.77 | KMT2A (0.43) | MAPTSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL4673533 | 0.77 | ENPP2 (0.44) | MAPTSMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL4672275 | 0.72 | ALDH1A1 (0.44) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL4660469 | 0.71 | KCNH2 (0.65) | KCNJ1KCNH2MAPTRAB9AKMT2A | |
| SCHEMBL4675660 | 0.70 | ROCK2 (0.56) | MAPTSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL4673681 | 0.70 | KMT2A (0.54) | MAPTSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL16833111 | 0.69 | RAB9A (0.86) | MAPTSMN1; SMN2RAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |